Data importation

Analyse des données de la publication corces: https://sci-hub.hkvisa.net/10.1038/ng.3646

General review of cell types in the data Corces

##  [1] "Intercept"                      "cell_subtype_LSC_vs_Blast"     
##  [3] "cell_subtype_CLP_vs_Blast"      "cell_subtype_Ery_vs_Blast"     
##  [5] "cell_subtype_LMPP_vs_Blast"     "cell_subtype_CMP_vs_Blast"     
##  [7] "cell_subtype_GMP_vs_Blast"      "cell_subtype_HSC_vs_Blast"     
##  [9] "cell_subtype_MEP_vs_Blast"      "cell_subtype_MPP_vs_Blast"     
## [11] "cell_subtype_Bcell_vs_Blast"    "cell_subtype_CD4Tcell_vs_Blast"
## [13] "cell_subtype_CD8Tcell_vs_Blast" "cell_subtype_Mono_vs_Blast"    
## [15] "cell_subtype_NKcell_vs_Blast"   "cell_subtype_pHSC_vs_Blast"
## [1] 0.4686074
## log2 fold change (MAP): cell subtype LSC vs Blast 
## Wald test p-value: cell subtype LSC vs Blast 
## DataFrame with 1 row and 5 columns
##       baseMean log2FoldChange     lfcSE    pvalue      padj
##      <numeric>      <numeric> <numeric> <numeric> <numeric>
## ACLY   766.956      -0.193179  0.182584  0.277684  0.468607

DESEQ Corces analysis

AML vs Normal (2cat)

## log2 fold change (MAP): cell type 2cat AML vs Normal 
## Wald test p-value: cell type 2cat AML vs Normal 
## DataFrame with 38625 rows and 5 columns
##            baseMean log2FoldChange      lfcSE     pvalue       padj
##           <numeric>      <numeric>  <numeric>  <numeric>  <numeric>
## A1BG       7.287774    2.51659e-06 0.00144268 0.35259131 0.51660349
## A1BG-AS1   3.016465    3.96550e-07 0.00144269 0.84363905 0.90473369
## A1CF       0.477729   -1.47974e-06 0.00144270 0.12567191 0.25249558
## A2M      108.158994   -2.38219e-05 0.00144279 0.00072023 0.00459217
## A2M-AS1   41.867227    1.27509e-06 0.00144268 0.66612506 0.78348696
## ...             ...            ...        ...        ...        ...
## ZXDC      301.79818    6.68706e-06 0.00144264 0.90430589 0.94365123
## ZYG11A      1.31018   -4.08458e-06 0.00144270 0.00141887 0.00795435
## ZYG11B    534.77660    1.05805e-05 0.00144258 0.61932494 0.74905997
## ZYX       364.66593   -2.36072e-06 0.00144269 0.29391869 0.45747509
## ZZEF1     805.28247   -1.60091e-05 0.00144267 0.00901750 0.03489449
## log2 fold change (MAP): cell type 2cat AML vs Normal 
## Wald test p-value: cell type 2cat AML vs Normal 
## DataFrame with 1 row and 5 columns
##       baseMean log2FoldChange      lfcSE    pvalue      padj
##      <numeric>      <numeric>  <numeric> <numeric> <numeric>
## ACLY   766.956   -2.91259e-05 0.00144273 0.0108176 0.0401399

ACLY exprimé différentiellement (padj= 0.0401704) entre les personnes atteintes d’AML et les non malades. Selon le boxplot, on peut émettre l’hypothèse qu’il serait moins exprimé chez les personnes leucémiques.

AML vs NormalBM (4cat)

## log2 fold change (MAP): cell type 4cat BMPB AML vs Normal BM 
## Wald test p-value: cell type 4cat BMPB AML vs Normal BM 
## DataFrame with 38625 rows and 5 columns
##            baseMean log2FoldChange      lfcSE     pvalue       padj
##           <numeric>      <numeric>  <numeric>  <numeric>  <numeric>
## A1BG       7.287774   -9.13954e-07 0.00144269   0.695044   0.808052
## A1BG-AS1   3.016465    3.46294e-07 0.00144269   0.823374   0.898095
## A1CF       0.477729   -4.58308e-07 0.00144269   0.962725   0.978246
## A2M      108.158994    1.03658e-06 0.00144269   0.612682   0.745603
## A2M-AS1   41.867227    3.01273e-07 0.00144269   0.897059   0.941457
## ...             ...            ...        ...        ...        ...
## ZXDC      301.79818   -2.04037e-06 0.00144266 0.70080530 0.81228574
## ZYG11A      1.31018   -2.32476e-07 0.00144269 0.84612719 0.91243415
## ZYG11B    534.77660    2.78613e-01 0.15472643 0.00173751 0.00790422
## ZYX       364.66593    3.65202e-07 0.00144269 0.84814543 0.91367401
## ZZEF1     805.28247   -2.53246e-06 0.00144263 0.71569099 0.82310647

## log2 fold change (MAP): cell type 4cat BMPB AML vs Normal BM 
## Wald test p-value: cell type 4cat BMPB AML vs Normal BM 
## DataFrame with 1 row and 5 columns
##       baseMean log2FoldChange     lfcSE     pvalue      padj
##      <numeric>      <numeric> <numeric>  <numeric> <numeric>
## ACLY   766.956      -0.230568  0.296703 0.00405713 0.0159898

ACLY exprimé différentiellemententre ces 2 sous groupes (padj= 0.0159897). Selon le boxplot, on peut encore une fois émettre l’hypothèse que ce gène serait moins exprimé chez les personnes leucémiques.

Subtype Where ACLY is most expressed vs all

##  [1] "Intercept"                      "cell_subtype_LSC_vs_Blast"     
##  [3] "cell_subtype_CLP_vs_Blast"      "cell_subtype_Ery_vs_Blast"     
##  [5] "cell_subtype_LMPP_vs_Blast"     "cell_subtype_CMP_vs_Blast"     
##  [7] "cell_subtype_GMP_vs_Blast"      "cell_subtype_HSC_vs_Blast"     
##  [9] "cell_subtype_MEP_vs_Blast"      "cell_subtype_MPP_vs_Blast"     
## [11] "cell_subtype_Bcell_vs_Blast"    "cell_subtype_CD4Tcell_vs_Blast"
## [13] "cell_subtype_CD8Tcell_vs_Blast" "cell_subtype_Mono_vs_Blast"    
## [15] "cell_subtype_NKcell_vs_Blast"   "cell_subtype_pHSC_vs_Blast"

ADD BOXPLOT AND VOLCANOPLOT pas nécessaire, à revoir avec vincent

Corrélation with ACLY gene in Corces

ACLY Corrélation analysis in all samples

Graph of correlation between ACLY and others genes in all samples

Heat map ot most correlate and anti-correlate genes to ACLY in all samples

ACLY Corrélation analysis in AML samples

Graph of correlation between ACLY and others genes in AML samples

Heat map of most correlate and anti-correlate genes to ACLY in AML samples

ACLY Corrélation analysis in Normal samples

Graph of correlation between ACLY and others genes in Normal samples

Heat map of most correlate and anti-correlate genes to ACLY in Normal samples

## ACLY Corrélation analysis in Normal_BM samples

ACLY Corrélation analysis in Normal_PB samples

Signature ACLY

##  [1] "ACLY"       "NUP93"      "UBE2I"      "PSMC3"      "AL356000.1"
##  [6] "MDH2"       "PPM1G"      "CYC1"       "SEC61A1"    "POLDIP2"   
## [11] "CCT5P1"     "COPG1"      "ICMT"       "MRPS34"     "PIGS"      
## [16] "CHID1"      "ZNF292"     "KLHL24"     "ZNF654"     "ZNF136"    
## [21] "CENPCP1"    "BRWD1"      "CENPC"      "BRAF"       "ZBED5"     
## [26] "GOSR1"      "N4BP2L2"
##  [1] "ACLY"       "NUP93"      "NME2P1"     "UBE2I"      "MYL6P5"    
##  [6] "COX6A1P2"   "ICMT"       "PSMD13"     "ATP5PBP6"   "DOLK"      
## [11] "RPP25L"     "AC012066.1" "PPIAP31"    "PMVK"       "ATP5ME"    
## [16] "LAMTOR2"    "DCAF7"      "AC015871.1" "MRPL34"     "RPS27P27"  
## [21] "PRDX5"      "GAPDHP1"    "HSPA8P7"    "UQCR11"     "POTEE"     
## [26] "PPP1CA"     "CHCHD2P2"   "GSS"        "COX8A"      "CCT3"      
## [31] "BCAP31"     "SRP14"      "MRPL11"     "COX17P1"    "UQCR10"    
## [36] "PPIAP22"    "TRMT112"    "TPI1"       "BUB3P1"     "SEC61A1"   
## [41] "SUMF2"      "TTC38"      "TNFAIP8L2"  "PPIA"       "MYL6P3"    
## [46] "PSMA7"      "PFN1P1"     "CDCA5"      "EDEM2"      "SREK1"     
## [51] "H3-3A"      "RBM27"      "KPNA5"      "ATRX"       "MIR3611"   
## [56] "BRAF"       "AP000766.1" "CTDSPL2"    "AC000123.3" "N4BP2L2"   
## [61] "CDK17"      "UBE3A"      "RTCA-AS1"   "YTHDC1"     "MYNN"      
## [66] "AC004696.1" "RLF"        "PP2D1"      "SKP1"       "MPP5"      
## [71] "KCNAB1"     "PKN2"       "EPC2"       "CRIPT"      "CENPCP1"   
## [76] "RNU6-1011P" "GOSR1"      "SLC35F5"    "ERO1B"      "AC055764.2"
## [81] "CENPC"
##   [1] "ACLY"         "DAG1"         "EIF3B"        "PIGS"         "TIMM50"      
##   [6] "PSMC3"        "TST"          "NECTIN1"      "ACADVL"       "MPST"        
##  [11] "CCT5P1"       "RITA1"        "EIF4G1"       "ANAPC5"       "YIF1B"       
##  [16] "NUP93"        "GUSB"         "CYC1"         "COPG1"        "SURF4"       
##  [21] "PTBP1"        "TTLL12"       "P4HB"         "POLDIP2"      "DDX41"       
##  [26] "BOP1"         "RPN2"         "CHID1"        "AL356000.1"   "ILF3"        
##  [31] "PMP22"        "CERS2"        "FAM234A"      "MED24"        "TMEM214"     
##  [36] "IDH2"         "ALDH4A1"      "LETM1"        "TXN2"         "DUS1L"       
##  [41] "POLR2L"       "EFTUD2"       "DDX39A"       "FARSA"        "GALE"        
##  [46] "UQCRC1"       "PLOD1"        "APEH"         "PTPA"         "ACOT7"       
##  [51] "MRPL28"       "WDR5"         "TYK2"         "PLOD3"        "SLC25A11"    
##  [56] "MRPS34"       "ALYREF"       "HYAL2"        "SEC61A1"      "PPM1G"       
##  [61] "ISOC2"        "AUP1"         "STK25"        "CLN6"         "KATNB1"      
##  [66] "AP2M1"        "HDLBP"        "MDH2"         "TESC"         "DDX49"       
##  [71] "DOT1L"        "MRPL4"        "CRAT"         "GRHPR"        "CSNK2A3"     
##  [76] "CARM1"        "PGP"          "RUSC1"        "PTBP1P"       "GPAA1"       
##  [81] "SLC35A4"      "TMEM164"      "TALDO1"       "PSMB2"        "GCDH"        
##  [86] "TMEM109"      "ARMC6"        "RUVBL2"       "LAMTOR2"      "PREB"        
##  [91] "AAAS"         "BSG"          "POLDIP3"      "NDUFB10"      "COMMD4"      
##  [96] "PES1"         "SDF2L1"       "PHPT1"        "MYDGF"        "TUFM"        
## [101] "EIF4A1P7"     "ZNRD2"        "PRPF19"       "COLGALT1"     "ADAM15"      
## [106] "CSNK2B"       "COASY"        "HYOU1"        "STOML2"       "ABCF2"       
## [111] "TPI1P1"       "AC098591.2"   "GTF3C5"       "NDUFAF3"      "MRPS2"       
## [116] "CAPNS1"       "IRAK1"        "HPS1"         "UBE2I"        "SRRT"        
## [121] "NUDC"         "AC025161.1"   "YBX1P6"       "FERMT3"       "DECR2"       
## [126] "TOP3A"        "PUF60"        "ACTN4P1"      "CAPN1"        "GANAB"       
## [131] "UBA1"         "GPS1"         "TPI1"         "TSC2"         "TOR2A"       
## [136] "HSD17B10"     "TMEM147"      "ACTN4"        "SHARPIN"      "VARS1"       
## [141] "INTS11"       "ROMO1"        "ADRM1"        "COPE"         "NDUFS8"      
## [146] "SND1"         "HRAS"         "HCFC1"        "SLC25A35"     "ECI1"        
## [151] "COMT"         "PSMD8"        "GSK3A"        "MPND"         "AC074134.1"  
## [156] "COQ4"         "PSMA7"        "SIGMAR1"      "EIF4A1P4"     "RNASEH2C"    
## [161] "RCC2P7"       "AC005102.1"   "TUBB4B"       "CHMP1A"       "C20orf27"    
## [166] "POFUT1"       "STK36"        "NDUFS6"       "BAG6"         "ERVK13-1"    
## [171] "TLK2"         "SENP7"        "FTX"          "AC097376.3"   "RFX3"        
## [176] "ZNF441"       "MPHOSPH8"     "KLHL24"       "WDR33"        "PUM2"        
## [181] "ZNF557"       "GOSR1"        "ARID4B"       "KMT2E"        "ZNF587"      
## [186] "ZNF493"       "LINC00641"    "NBPF15"       "KMT2A"        "NFYC-AS1"    
## [191] "CCDC18-AS1"   "TRNT1"        "ZNF397"       "EIF4A2P4"     "RBM26"       
## [196] "CENPCP1"      "TRAPPC2B"     "EIF4A2"       "SMAD4"        "BRAF"        
## [201] "MARCHF7"      "ZNF264"       "CHORDC1"      "ZNF292"       "AC104806.2"  
## [206] "TMEM161B-AS1" "EBLN3P"       "ZC3H6"        "THAP6"        "RC3H2"       
## [211] "ZNF136"       "GPBP1"        "DMTF1"        "CENPC"        "RPL41"       
## [216] "KAT6A"        "YTHDC1"       "RPL21"        "ZNF654"       "TPT1-AS1"    
## [221] "AC131206.1"   "BRWD1"        "ZNF430"       "GCC2"         "AP000648.4"  
## [226] "RASA1"        "PIBF1"        "ARRDC3"       "PPWD1"        "AC092070.2"  
## [231] "NBPF11"       "LSM8"         "N4BP2L2"      "ZBED5"        "CBWD5"
##   [1] "ACLY"        "ANAPC5"      "TIMM50"      "MCM2"        "SMARCAL1"   
##   [6] "ILF3"        "STOML2"      "NUP210"      "B4GALT2"     "GATB"       
##  [11] "POLDIP2"     "MPST"        "TTLL12"      "WDR5"        "AC005102.1" 
##  [16] "AC092042.2"  "EIF3B"       "ALYREF"      "TADA3"       "PIGS"       
##  [21] "FBLN2"       "GALE"        "MCM7"        "BOP1"        "LETM1"      
##  [26] "AC098591.2"  "SURF4"       "CCT5P1"      "DAG1"        "RBM14"      
##  [31] "ALDH4A1"     "APEH"        "YIF1B"       "PSMC3"       "COQ4"       
##  [36] "CENPX"       "CYC1"        "TYK2"        "AC025161.1"  "H1-5"       
##  [41] "CCT3"        "MTHFD1P1"    "ACADVL"      "SIGMAR1"     "MED24"      
##  [46] "YBX1P6"      "MRPS7"       "UQCRC1"      "SLC35A4"     "PMPCA"      
##  [51] "BOLA2P1"     "ACOT7"       "DUS1L"       "TNPO2"       "CLN6"       
##  [56] "STK25"       "NUP93"       "IDH2"        "IRAK1"       "GCAT"       
##  [61] "RPS21"       "DDX39A"      "RUSC1"       "POLD2"       "CENPUP1"    
##  [66] "NDUFB10"     "MCM5"        "NELFCD"      "PGP"         "PRDX4"      
##  [71] "AAAS"        "AL356000.1"  "FARSA"       "PHKG2"       "TST"        
##  [76] "TXN2"        "AUP1"        "SMG5"        "POLE"        "KARS1"      
##  [81] "RPN2"        "PMP22"       "E2F1"        "CHID1"       "XRCC6P3"    
##  [86] "MRPL54"      "PLOD3"       "GCN1"        "INTS11"      "NECTIN1"    
##  [91] "KLHDC3"      "PTBP1"       "AC013244.1"  "FCGRT"       "NDUFA3"     
##  [96] "AC011753.3"  "GCDH"        "FARS2"       "MT-TL1"      "RNPS1"      
## [101] "DAD1"        "MORN2"       "OGDH"        "HNRNPA1P28"  "AL161636.2" 
## [106] "ACTBP2"      "CLPTM1"      "S100A6"      "Z93019.1"    "ARPC4"      
## [111] "PRDX2P2"     "GPS1"        "HMGB3P8"     "C11orf24"    "DHRS3"      
## [116] "AL031229.1"  "DDX41"       "AC138932.4"  "DNM2"        "RPL14P3"    
## [121] "RAB5C"       "P4HB"        "EFTUD2"      "COX5B"       "ELAC2"      
## [126] "RANP5"       "TK1"         "PREB"        "CARM1"       "AC079328.1" 
## [131] "SF3B5"       "TMCO6"       "TALDO1"      "ERAL1"       "MRPL4"      
## [136] "EIF4G1"      "GUSB"        "NDUFS6"      "RFXANK"      "NDUFB9P2"   
## [141] "TUFM"        "LRPAP1"      "AL357134.1"  "PRPF19"      "RNASEH2C"   
## [146] "IPO5"        "PPM1G"       "DCXR"        "ACTG1P14"    "PTPA"       
## [151] "NDUFB4"      "GATAD2A"     "AC026410.1"  "PLOD1"       "TMEM147"    
## [156] "NPM1P4"      "FLOT2"       "MRPS34"      "SNRPA"       "PPIAP71"    
## [161] "LAGE3"       "AHCYP4"      "TMEM109"     "VPS25"       "AC133435.1" 
## [166] "CDV3P1"      "DDX49"       "ATP5PBP7"    "NDUFB11P1"   "RITA1"      
## [171] "CYCSP51"     "MRPS2"       "DNTTIP1"     "ARAF"        "TPM3P4"     
## [176] "AC107983.1"  "MDH2"        "YIF1A"       "NDUFS5P5"    "ARMC6"      
## [181] "TMEM141"     "THAP4"       "NPM1P9"      "AL358934.1"  "SLC5A6"     
## [186] "UBA52P3"     "PRELID1P1"   "SRRT"        "DRAP1"       "EBP"        
## [191] "AC005262.1"  "LDB1"        "AC074134.1"  "MYDGF"       "NCAPH2"     
## [196] "AL021877.1"  "RPL19P21"    "POLR3H"      "TYMSP2"      "MORF4L1P3"  
## [201] "CLUHP6"      "TPCN1"       "NELFE"       "FECHP1"      "RPS4XP9"    
## [206] "BTF3P13"     "NHP2P2"      "ABCF3"       "RPL7P20"     "PTBP1P"     
## [211] "FAM234A"     "MYL6P4"      "ARF1"        "SEC24C"      "SHARPIN"    
## [216] "RPL12P13"    "SLC25A11"    "PPIAP65"     "RPL4P1"      "GTF3C5"     
## [221] "RPL7P36"     "RPUSD3"      "AC010376.1"  "PFN1P9"      "PAICSP2"    
## [226] "CENPT"       "RPL8P2"      "HPS1"        "AC008799.1"  "POLR2L"     
## [231] "ACTBP8"      "AC090312.2"  "AL021407.2"  "CERS2"       "CHMP1A"     
## [236] "GET3"        "UBA1"        "MTHFD1"      "THOP1"       "FTSJ1"      
## [241] "RPL7P13"     "GRHPR"       "AC016734.1"  "FP565171.1"  "BAG6"       
## [246] "PAICSP3"     "SYNGR2"      "NME4"        "AL451050.1"  "CNN2P10"    
## [251] "COPG1"       "ATP5MC1"     "AF241726.1"  "MAZ"         "BTF3L4P1"   
## [256] "AC097713.2"  "DHX16"       "ACTG1P19"    "ELOB"        "CAPN1"      
## [261] "COLGALT1"    "POLR2I"      "AC074281.1"  "HDLBP"       "USB1"       
## [266] "MTCO1P40"    "WBP11P1"     "HPS6"        "FOXRED1"     "AC012671.1" 
## [271] "EIF5AP4"     "CRAT"        "RANGAP1"     "C19orf48"    "MRPL28"     
## [276] "SEC61A1"     "EMD"         "NDUFS5"      "SUMO2P6"     "CPSF4"      
## [281] "AP005431.2"  "EBNA1BP2"    "ATP5MC1P6"   "ZNF606"      "FBXW11"     
## [286] "AC097376.3"  "PCMTD1"      "RBM26"       "HECTD2"      "AL133243.2" 
## [291] "GOLGB1"      "VPS54"       "ZNF136"      "ZNF12"       "RYBP"       
## [296] "MIR570"      "AC211476.12" "AC103724.4"  "LPAR6"       "AL021368.2" 
## [301] "FAM111A"     "RSBN1L"      "ZBTB20-AS3"  "PIBF1"       "TNRC6C"     
## [306] "NUMB"        "RFX3"        "CENPCP1"     "GON4L"       "RBBP6"      
## [311] "RIC8B"       "MIR17HG"     "ZNF430"      "ZNF587"      "MFSD6"      
## [316] "LINC00342"   "BRAF"        "UBE3A"       "SS18L1"      "GARS-DT"    
## [321] "ATP8B1"      "CPEB3"       "ZNF493"      "GOSR1"       "SETX"       
## [326] "EBLN3P"      "ZNF397"      "OTUD4"       "TTC33"       "TLK2"       
## [331] "BRWD1"       "LRCH3"       "CBWD5"       "RPL21"       "HIF1A"      
## [336] "ZNF518A"     "AL050309.1"  "RASA1"       "AC010186.3"  "KLHL24"     
## [341] "SECISBP2L"   "NBPF14"      "ANKRD36C"    "AC020661.3"  "AGPS"       
## [346] "NUFIP2"      "RNU11-2P"    "Z95114.3"    "AC009120.2"  "RC3H2"      
## [351] "NEK7"        "RAB8B"       "LINC00641"   "ROCK1"       "DLEU2L"     
## [356] "AC131206.1"  "NUDT13"      "KAT6A"       "HIF1AP1"     "YTHDC1"     
## [361] "CHORDC1"     "AC068587.4"  "KANSL1L"     "BOD1L1"      "N4BP2L2"    
## [366] "AC114980.1"  "SENP6"       "ARRDC3"      "KMT2E"       "RLIM"       
## [371] "MAGOH2P"     "PPWD1"       "TNKS"        "SPAG9"       "FTX"        
## [376] "NFYC-AS1"    "BPTF"        "ZFC3H1"      "RPL41"       "ELK4"       
## [381] "SMAD4"       "CHD1"        "AC139769.1"  "GABPB1"      "ZC3H6"      
## [386] "MARCHF7"     "NBPF11"      "LCORL"       "LSM8"        "GOPC"       
## [391] "LRRC37A"     "CHD9"        "RBM12B"      "NBPF15"      "TRAPPC2B"   
## [396] "ATRX"        "PRPF38A"     "ZNF772"      "ERVK13-1"    "NIFK-AS1"   
## [401] "TPT1P9"      "JRKL"        "AC024075.2"  "AC138409.2"  "AC092070.2" 
## [406] "ZNF557"      "ZNF264"      "RTN4"        "TERF1"       "GCC2"       
## [411] "N4BP1"       "FAM228B"     "RAB22A"      "ARID4B"      "TPT1-AS1"   
## [416] "CENPC"       "ZNF654"      "LMBRD1"      "FBXO11"      "ZBED5"      
## [421] "ARHGAP5"     "AL353743.1"
##    [1] "ACLY"         "CTSD"         "ARPC4"        "COMMD5"      
##    [5] "USB1"         "SLC25A35"     "CDKN2D"       "LAMP1"       
##    [9] "RPS6KA1"      "CAP1"         "XKR8"         "RRBP1"       
##   [13] "COPG1"        "CAPNS1"       "DAG1"         "IFITM3"      
##   [17] "REEP4"        "FURIN"        "PLOD1"        "CBX6"        
##   [21] "AP2A1"        "CFL1"         "PIGS"         "G6PD"        
##   [25] "CLIC1"        "GADD45B"      "WDR45P1"      "SLC35F6"     
##   [29] "ITGB2"        "CDIP1"        "CHFR"         "ARHGAP30"    
##   [33] "TLN1"         "C15orf39"     "ADAM8"        "ADAP1"       
##   [37] "BCAP31"       "ACTBP1"       "MYO1F"        "POLR2L"      
##   [41] "EIF6"         "ACTR1A"       "ZNHIT1"       "HCLS1"       
##   [45] "P4HB"         "TRAPPC1"      "BAIAP2"       "MSNP1"       
##   [49] "MAPKAPK2"     "CCDC69"       "FHOD1"        "MRPL28"      
##   [53] "MGAT1"        "PREX1"        "NAA60"        "GID8"        
##   [57] "ELF4"         "TSPOAP1"      "SLC1A5"       "TPM3P8"      
##   [61] "LGALS1"       "RITA1"        "PLCB2"        "TMEM214"     
##   [65] "BRD3"         "CAP1P2"       "TGFB1"        "ACTN4"       
##   [69] "GAK"          "ACTN4P1"      "H6PD"         "WBP1L"       
##   [73] "NECTIN1"      "AAMP"         "CYB561D2"     "VCP"         
##   [77] "COX8A"        "IDH2"         "CDIPT"        "MYL6P5"      
##   [81] "EIF4G1"       "PLEKHM1"      "TNRC18"       "ATP6AP1"     
##   [85] "VPS16"        "MFSD10"       "PTPN18"       "MARS1"       
##   [89] "LMAN2"        "NARF"         "TUBB4B"       "TCIRG1"      
##   [93] "GANAB"        "TNFSF12"      "EFHD2"        "TMED9"       
##   [97] "TYK2"         "MOB3A"        "SURF4"        "BSG"         
##  [101] "ITPK1"        "GBA"          "KLF13"        "ARHGAP1"     
##  [105] "GSTP1"        "TLE4"         "EEF1AKMT4"    "CTDSP1"      
##  [109] "ARHGAP27"     "YIPF3"        "GSK3A"        "ADCY7"       
##  [113] "UBE2I"        "RCC2P6"       "INCENP"       "FERMT3"      
##  [117] "STK40"        "KIAA0895L"    "GNAI2"        "RHOG"        
##  [121] "PRDX5"        "ZDHHC12"      "SLC9A1"       "PPP1R18"     
##  [125] "ARAP1"        "AUP1"         "MAP2K3"       "RAB35"       
##  [129] "RAB8A"        "NFKBIB"       "SLC25A11"     "GNB1"        
##  [133] "AC026462.1"   "SDF2L1"       "KEAP1"        "AC093700.2"  
##  [137] "TESC"         "MAST2"        "LIMK1"        "TST"         
##  [141] "FLOT1"        "ATP6V0D1"     "HYAL2"        "OS9"         
##  [145] "MAST3"        "MAP3K11"      "SNAPC2"       "KCNAB2"      
##  [149] "P3H1"         "DOK1"         "PDIA4"        "SHC1"        
##  [153] "PSMD2"        "CD151"        "COASY"        "EFNB1"       
##  [157] "PPP1R12C"     "CTDNEP1"      "PPCDC"        "HDGFL2"      
##  [161] "POLDIP3"      "OSBPL5"       "ENG"          "SEC16A"      
##  [165] "COPS7A"       "CDK2AP2"      "AC026877.1"   "CANT1"       
##  [169] "NLRX1"        "CDC37"        "TPD52L2"      "AC023157.1"  
##  [173] "SIRT2"        "CFL1P2"       "EDEM2"        "FBXL19"      
##  [177] "DNAJC5"       "CISD3"        "IMPDH1"       "PDLIM2"      
##  [181] "ZFP36"        "TBC1D10B"     "SNAI3"        "MEF2D"       
##  [185] "DNM2"         "ACADVL"       "FHL3"         "SYNGR1"      
##  [189] "AL159141.1"   "RAB5C"        "NBEAL2"       "TNFRSF1B"    
##  [193] "MAD2L2"       "TOLLIP"       "PTGES2"       "CATSPER1"    
##  [197] "JOSD2"        "FLNA"         "ABHD4"        "SLC27A3"     
##  [201] "ARPC2"        "RIC8A"        "CALHM2"       "ZMIZ1"       
##  [205] "DGKZP1"       "INPPL1"       "ABR"          "PYCARD"      
##  [209] "NACC1"        "GUSB"         "SNX33"        "HSD17B10"    
##  [213] "WDR1"         "BST2"         "PISD"         "CTNS"        
##  [217] "BORCS8"       "MAML1"        "SSH3"         "TSPAN17"     
##  [221] "PIP5K1C"      "SFXN5"        "SH3BGRL3"     "LBX2-AS1"    
##  [225] "WAS"          "SCRIB"        "IL27"         "APOBR"       
##  [229] "DGKZ"         "MMP25"        "COMT"         "SLC35A4"     
##  [233] "ATG13"        "AC138932.4"   "YIF1B"        "VPS11"       
##  [237] "DMAC2"        "WDTC1"        "RTF2"         "GTF3C1"      
##  [241] "PLCB3"        "RTL8C"        "GHDC"         "ANXA2P3"     
##  [245] "EMP3"         "ZNF213"       "SNX17"        "ZNF362"      
##  [249] "ELOVL1"       "TMEM184B"     "PTPA"         "MFN2"        
##  [253] "RAB5CP2"      "PRKACA"       "TM9SF4"       "TANGO2"      
##  [257] "CD2BP2"       "IFITM2"       "ACP2"         "SLC27A4"     
##  [261] "STK11IP"      "PLXND1"       "POTEF"        "NUCB1"       
##  [265] "PSMA7"        "OSBPL2"       "EIF3B"        "ZNF282"      
##  [269] "AKT1"         "DDX41"        "SCAMP4"       "ADAM15"      
##  [273] "TMEM109"      "CCDC159"      "HPS6"         "COLGALT1"    
##  [277] "MAPKAPK3"     "G6PC3"        "COPE"         "CAPN1"       
##  [281] "DCTN3"        "PLOD3"        "FAM32A"       "MOGS"        
##  [285] "NOC4L"        "TWF2"         "AC006970.1"   "SPSB2"       
##  [289] "PSMB6"        "MYO9B"        "UNC13D"       "LSP1"        
##  [293] "TUBGCP2"      "GMIP"         "PSAP"         "GPKOW"       
##  [297] "PEPD"         "PPP1R26"      "PSMB2"        "AGTRAP"      
##  [301] "ZNF646"       "ANTKMT"       "UNC45A"       "BLOC1S1"     
##  [305] "SCNM1"        "ACTBP9"       "AP2A2"        "ABHD12"      
##  [309] "TMEM250"      "LMNB2"        "ADCY9"        "CSNK2A3"     
##  [313] "UNC119"       "MFSD5"        "MED29"        "LAMTOR2"     
##  [317] "ACTB"         "IFI35"        "AP3D1"        "SHKBP1"      
##  [321] "CSNK1D"       "MARCHF2"      "PSMD4"        "FMNL1"       
##  [325] "CTSA"         "TPI1P1"       "GLYR1"        "GPAA1"       
##  [329] "AL354989.2"   "AC016734.1"   "PBX2"         "SF3B2"       
##  [333] "CAMKK2"       "GBA2"         "KATNB1"       "ITGAX"       
##  [337] "FIBP"         "PSME2"        "HCFC1R1"      "AC023232.1"  
##  [341] "CHMP2A"       "CDK5"         "PRELID1"      "ICMT"        
##  [345] "SLC27A1"      "HTT"          "SH2D3C"       "DEDD2"       
##  [349] "EXOSC4"       "DOK2"         "APEX2"        "RAB7A"       
##  [353] "PEAK3"        "DDOST"        "MYDGF"        "ANAPC2"      
##  [357] "DOT1L"        "TRIOBP"       "LDHAP5"       "SLC29A3"     
##  [361] "ZDHHC3"       "GPR35"        "H2AX"         "ARF1"        
##  [365] "GRAMD4"       "RXRA"         "PPM1F"        "ULK1"        
##  [369] "TMEM115"      "FBXO6"        "VAV1"         "GNPTG"       
##  [373] "LDLR"         "EFTUD2"       "AL121723.1"   "NCOA6"       
##  [377] "ISOC2"        "PSME3"        "MCRIP1"       "PSMC4"       
##  [381] "NOTCH1"       "RAB1B"        "MSRB1"        "NKIRAS2"     
##  [385] "BABAM1"       "TXLNA"        "CCDC88B"      "CERS2"       
##  [389] "MRPS34"       "ARL8A"        "GAPDH"        "POTEE"       
##  [393] "NDUFS8"       "FAM50A"       "CHMP1A"       "ADRM1"       
##  [397] "ZYX"          "TYROBP"       "TRABD"        "AP2M1"       
##  [401] "Z97180.1"     "SDF4"         "LAMTOR1"      "MBD3"        
##  [405] "HNRNPAB"      "MRGBP"        "KLF16"        "ANAPC11"     
##  [409] "ESRRA"        "RNF44"        "TMEM11"       "UBN1"        
##  [413] "SLC38A10"     "CD99L2"       "GAPDHP60"     "UBE2L6"      
##  [417] "EHD1"         "COMMD4"       "PRELID1P1"    "ITPRIP"      
##  [421] "HRAS"         "FBXW5"        "PLEKHO2"      "SEC61A1"     
##  [425] "BRPF1"        "PGAP6"        "NRROS"        "TOP3A"       
##  [429] "HYOU1"        "SSH1"         "TMEM164"      "WDR13"       
##  [433] "COQ8A"        "PORCN"        "GRK2"         "ATP6V1F"     
##  [437] "PRKCSH"       "RAC2"         "ZNRD2"        "CLPTM1L"     
##  [441] "MARK4"        "IPO13"        "PSMB3"        "RTL8A"       
##  [445] "FAM234A"      "PNPLA6"       "OTUB1"        "HSPA7"       
##  [449] "PLEKHM1P1"    "PSMC3"        "FRMD8"        "RGS19"       
##  [453] "PLD3"         "EIF4A1P4"     "CDK9"         "FAM214B"     
##  [457] "EHBP1L1"      "RNF166"       "FLYWCH2"      "GYS1"        
##  [461] "IDH3G"        "TUBA1B"       "BLVRB"        "RNH1"        
##  [465] "AKT1S1"       "MPV17L2"      "IGF2R"        "TMEM104"     
##  [469] "C19orf25"     "ANKRD13D"     "RELA"         "TAPBPL"      
##  [473] "NUP93"        "NCSTN"        "GALNT6"       "SLC26A6"     
##  [477] "MSN"          "KSR1"         "EMC8"         "DNAJB12"     
##  [481] "RIPK3"        "PHC2"         "ARFGAP1"      "MAPK7"       
##  [485] "PTBP1"        "CYC1"         "MAP2K7"       "CAMTA2"      
##  [489] "STARD3"       "TIMP1"        "HPS1"         "SAT2"        
##  [493] "CREB3"        "PITPNM1"      "TRIM11"       "ADGRE5"      
##  [497] "PTTG1IP"      "SLC4A2"       "PLIN3"        "STX4"        
##  [501] "NCOR2"        "DHX8"         "DPYSL2"       "CSNK2B"      
##  [505] "PHPT1"        "HLA-B"        "PUF60"        "GRN"         
##  [509] "LRPAP1"       "CLPTM1"       "ANXA2P1"      "TBC1D9B"     
##  [513] "MIDN"         "MVP"          "ATP6V0CP3"    "PSTPIP1"     
##  [517] "MARK2"        "HIVEP3"       "HDLBP"        "AMPD2"       
##  [521] "HNRNPKP2"     "RALBP1"       "BATF"         "PIGQ"        
##  [525] "DDX49"        "CCND3P1"      "FAM89B"       "CORO1A"      
##  [529] "ZNF710"       "SLC52A2"      "RNPEP"        "ZNF787"      
##  [533] "TTC31"        "KDELR1"       "SHISA5"       "LYPLA2"      
##  [537] "PREB"         "AP2S1"        "THEMIS2"      "HIPK2"       
##  [541] "PPP4C"        "TBCB"         "AP002414.4"   "SRPRA"       
##  [545] "ENO1"         "PGP"          "TPI1"         "TMBIM1"      
##  [549] "VPS53"        "PYGB"         "MED11"        "CD300LB"     
##  [553] "STX18"        "MRPS12"       "PSMD13"       "CTBP2P8"     
##  [557] "RNPEPL1"      "NAPA"         "NUP62"        "KIAA2013"    
##  [561] "TEDC1"        "RABL6"        "DECR2"        "GNB2"        
##  [565] "CNPY3"        "IFI27L2"      "GLMP"         "MDH2"        
##  [569] "PDE6G"        "ISY1"         "TESK1"        "STXBP2"      
##  [573] "SCAMP2"       "FBP1"         "RHOC"         "CASC3"       
##  [577] "CD300C"       "AL596087.1"   "LRRC8A"       "UBE2Q1"      
##  [581] "DDRGK1"       "CERCAM"       "ZSWIM8"       "CCAR2"       
##  [585] "LASP1"        "POMGNT2"      "ABCF2"        "MBOAT7"      
##  [589] "UBE2J2"       "LSM10"        "LCP1"         "UROD"        
##  [593] "SCYL1"        "HK1"          "PARP10"       "AL080243.2"  
##  [597] "HMOX1"        "PPP1CA"       "SP2"          "AC020629.1"  
##  [601] "WDR25"        "TUBG1"        "NDUFV1"       "CPAMD8"      
##  [605] "TOR2A"        "GATAD2A"      "ATG2A"        "PTPN9"       
##  [609] "SHARPIN"      "TMEM53"       "USP4"         "SLC38A7"     
##  [613] "CARD19"       "E2F4"         "NADK"         "DYSF"        
##  [617] "PTPN6"        "RBM42"        "SNX32"        "ATP5F1B"     
##  [621] "CTRC"         "PPP6R1"       "ELOF1"        "MCRS1"       
##  [625] "SIPA1"        "CCT5P1"       "DUS1L"        "TNK2-AS1"    
##  [629] "VASP"         "STAT3"        "CRAT"         "MGRN1"       
##  [633] "PIK3R5"       "STK11"        "PDE4A"        "STEAP3"      
##  [637] "MIIP"         "RUVBL2"       "TMEM91"       "CCDC12"      
##  [641] "GET3"         "ZNF598"       "U2AF2"        "RPUSD3"      
##  [645] "MYO1G"        "ABCD1"        "MAP2K1P1"     "UBE2D3P2"    
##  [649] "TK2"          "ZC3H18"       "NECAB3"       "TRPV2"       
##  [653] "CHID1"        "UQCRC1"       "CNP"          "RBCK1"       
##  [657] "SLC10A3"      "ATP13A2"      "GSS"          "DGAT1"       
##  [661] "MLX"          "TECPR2"       "TMEM161A"     "NPLOC4"      
##  [665] "PRKCD"        "TXN2"         "IL27RA"       "ZNF316"      
##  [669] "CST3"         "EIF4A1P7"     "PKN1"         "IP6K1"       
##  [673] "HNRNPUL1"     "SMARCA4"      "LSP1P3"       "NCLN"        
##  [677] "IQCE"         "ZBTB45"       "SLC45A4"      "ALAS1"       
##  [681] "RPN2"         "LRP10"        "ISG15"        "APOA2"       
##  [685] "CTNNBIP1"     "FLII"         "SZRD1"        "CUEDC2"      
##  [689] "ATOX1"        "ICAM1"        "ACTBP8"       "NRBP1"       
##  [693] "RPS19BP1"     "ADGRA2"       "TMEM39B"      "TRIM8"       
##  [697] "LRRC41"       "STUB1"        "ZBED1"        "ZNF384"      
##  [701] "SLC6A6"       "GAA"          "SAMD4B"       "VPS28"       
##  [705] "EIF2AK1"      "PSMB4"        "GALNT2"       "RNF167"      
##  [709] "COPZ1"        "RNF123"       "C7orf26"      "PHRF1"       
##  [713] "RABGGTA"      "CRELD2"       "CMTM1"        "CLTB"        
##  [717] "SCAMP3"       "DYNLL1P2"     "MAP1S"        "UBA7"        
##  [721] "SEC24C"       "CAVIN2"       "SGPL1"        "PFN1P1"      
##  [725] "MAP3K6"       "TICAM1"       "ZZEF1"        "FOXJ2"       
##  [729] "MOSPD3"       "TSPO"         "ECHS1"        "GAPDHP65"    
##  [733] "SIGLEC9"      "IL15RA"       "MVB12A"       "SRA1"        
##  [737] "SMIM12"       "ZBTB7B"       "DPP9"         "SF3B4"       
##  [741] "KCNH3"        "FBXL18"       "GLIPR2"       "SASH3"       
##  [745] "HGS"          "KMT2D"        "ARRDC1"       "AC087499.4"  
##  [749] "CYB5R3"       "TMEM205"      "TMEM127"      "RENBP"       
##  [753] "SDHB"         "GSDMD"        "AC116049.1"   "TCF25"       
##  [757] "MT2P1"        "MOB2"         "MED15"        "ACTG1P14"    
##  [761] "SLC9A3R1"     "GRHPR"        "ARAP3"        "PI4KA"       
##  [765] "TALDO1"       "CHST14"       "C20orf27"     "EMC10"       
##  [769] "ARSG"         "MBD6"         "RPS6KA4"      "NSMF"        
##  [773] "CIC"          "PSMB10"       "OGDH"         "TTYH3"       
##  [777] "HS1BP3"       "ACTBP2"       "MAP7D1"       "BCKDK"       
##  [781] "EXTL3"        "CTBP2P4"      "CYBA"         "YIPF2"       
##  [785] "TSC2"         "PIEZO1"       "AATBC"        "ZFAND3"      
##  [789] "PRSS36"       "PTPN23"       "CMIP"         "AL356000.1"  
##  [793] "PSME2P6"      "MLF2"         "CCIN"         "PHETA2"      
##  [797] "IVD"          "TBC1D2"       "TMEM63B"      "GALE"        
##  [801] "PDLIM7"       "RAI1"         "MPND"         "PSMD8"       
##  [805] "PACS2"        "NCKAP5L"      "ARMC7"        "GIT1"        
##  [809] "AL139246.5"   "CHPF2"        "KCTD17"       "TMEM179B"    
##  [813] "PSME3IP1"     "MKNK2P1"      "ALG1L15P"     "FADS1"       
##  [817] "PITPNA"       "NME3"         "UQCR11"       "GUK1"        
##  [821] "MAP2K2"       "MON1B"        "ATP5F1D"      "UBE2M"       
##  [825] "TCHP"         "SPECC1"       "AC015912.3"   "BCL3"        
##  [829] "SLAMF8"       "DPAGT1"       "GAPDHP63"     "CFL1P4"      
##  [833] "RNF40"        "WDR45"        "ZNF366"       "TRAF7"       
##  [837] "FAM78A"       "TSC22D4"      "FUOM"         "CYHR1"       
##  [841] "TMEM94"       "SYN2"         "PHF21A"       "DDX39A"      
##  [845] "PAXX"         "NMT1"         "STAT6"        "AC018413.1"  
##  [849] "DYNLL1P3"     "INAFM1"       "ARSA"         "SLC2A3P2"    
##  [853] "C19orf47"     "ATF6B"        "NAGPA"        "GRK4"        
##  [857] "HMG20B"       "UBAC1"        "GBF1"         "SUGP1"       
##  [861] "DGCR2"        "AC020893.2"   "TMEM259"      "IRAK1"       
##  [865] "GALNS"        "MAN2B2"       "DHX16"        "CLN6"        
##  [869] "MEA1"         "RPN1"         "POLDIP2"      "CTBP1"       
##  [873] "SPR"          "MTCH1"        "DNASE2"       "REPIN1"      
##  [877] "TAF1C"        "EIF2B1"       "HGH1"         "AC010997.6"  
##  [881] "DYNC1H1"      "ECI1"         "CCDC9"        "TOR4A"       
##  [885] "ANXA2P2"      "IRF7"         "TSPAN4"       "ECH1"        
##  [889] "POR"          "LGALS2"       "MAN2A2"       "CEBPD"       
##  [893] "MT2A"         "ITGAM"        "STRN4"        "MAN1B1"      
##  [897] "FOXK2"        "AHRR"         "RCC2"         "ATG4D"       
##  [901] "TMEM120A"     "PDXK"         "MRTFA"        "RNF181"      
##  [905] "CENPB"        "CLTA"         "AC243960.2"   "TET2"        
##  [909] "CNDP2"        "TMBIM6"       "CAPN15"       "GLULP4"      
##  [913] "TAOK2"        "BAG6"         "SRF"          "ZNF865"      
##  [917] "SLC35E1"      "PSME1"        "LAMTOR4"      "DDB1"        
##  [921] "MYH9"         "GPBAR1"       "ROMO1"        "VAMP5"       
##  [925] "DOHH"         "PTMS"         "CAPZB"        "TADA3"       
##  [929] "AC004687.1"   "TAF4"         "NADSYN1"      "PFN1"        
##  [933] "COX6A1P2"     "PSMD9"        "BAP1"         "AATK"        
##  [937] "PPP1R9B"      "ZNF358"       "CABLES2"      "OTUD5"       
##  [941] "TMEM150B"     "PGD"          "ARID3B"       "TMEM129"     
##  [945] "EXOC3"        "GLULP3"       "GLT1D1"       "GTPBP2"      
##  [949] "FOXN3"        "GOLGA8K"      "PGK1P2"       "ELOB"        
##  [953] "LYPLA2P1"     "HCST"         "HSPA6"        "LST1"        
##  [957] "SMARCD2"      "CD300LF"      "ANXA2"        "M1AP"        
##  [961] "TAPBP"        "DNASE1L1"     "MGAT4B"       "MCOLN1"      
##  [965] "AC069366.2"   "TUBB"         "AC104695.2"   "TRIM26"      
##  [969] "RHOQP1"       "PGDP1"        "SRC"          "NELFB"       
##  [973] "B3GALT6"      "ZNF516"       "HCFC1"        "APEH"        
##  [977] "DPEP2"        "PI4K2A"       "ASL"          "SQSTM1"      
##  [981] "RAVER1"       "ATP6V0B"      "CSF1R"        "ABHD17AP1"   
##  [985] "COPS9"        "SPATA20"      "SPATA20P1"    "TNFAIP2"     
##  [989] "MPG"          "RNF217-AS1"   "CEBPB"        "SH3PXD2B"    
##  [993] "MYD88"        "FAM174C"      "POLR2E"       "MAF1"        
##  [997] "LTBR"         "LLGL1"        "PIAS3"        "RAB6D"       
## [1001] "TMC4"         "UBL4A"        "POLR2F"       "PCBD1"       
## [1005] "CYBC1"        "TKT"          "PES1"         "MIR22HG"     
## [1009] "MYL6P1"       "OAF"          "WBP2"         "PRR14"       
## [1013] "PMP22"        "NUBP2"        "VCAN"         "PIGT"        
## [1017] "VPS39"        "ARID1A"       "CPVL"         "WDR81"       
## [1021] "AC079944.2"   "CBX4"         "USP19"        "BAG1"        
## [1025] "UBA1"         "GPS1"         "PTBP1P"       "ACTBP7"      
## [1029] "ABI3"         "CCDC149"      "PRRC2A"       "FCGR2A"      
## [1033] "FAM110A"      "CMTM2"        "CHMP4BP1"     "ZNF467"      
## [1037] "COG7"         "NDUFV3"       "TEPSIN"       "CSF3R"       
## [1041] "ZSWIM4"       "UBXN6"        "ATG9A"        "AC006483.1"  
## [1045] "VSIR"         "PLPPR2"       "PAK4"         "AL158201.1"  
## [1049] "WBP1LP2"      "MAP3K3"       "CEACAM3"      "AC060766.5"  
## [1053] "CCT5P2"       "CCR1"         "ADGRE2"       "NISCH"       
## [1057] "PIK3R6"       "RAB11B"       "PGLS"         "ANKS1A"      
## [1061] "PTDSS2"       "SH3GL1"       "DDX54"        "NAPRT"       
## [1065] "ACAP3"        "PCAT7"        "P2RY6"        "RPS15AP30"   
## [1069] "CLEC10A"      "GAPDHP70"     "MPST"         "C19orf38"    
## [1073] "PPM1M"        "PPM1G"        "SESN2"        "MIF4GD"      
## [1077] "MON1A"        "VAC14"        "ZNF628"       "NLRP9P1"     
## [1081] "AC103988.1"   "ZNF746"       "CYP2S1"       "P2RY10"      
## [1085] "EYS"          "PLCE1"        "AC093110.1"   "MZT1"        
## [1089] "WDR89"        "TAF7"         "RPL22P2"      "COL10A1"     
## [1093] "ZNF14"        "WDR36"        "CMSS1"        "ERO1B"       
## [1097] "EIF4A2P4"     "CEP57"        "SBDSP1"       "NUFIP1P1"    
## [1101] "NFYB"         "AL450384.2"   "CMPK1"        "RC3H2"       
## [1105] "SELENOP"      "TRMT10C"      "IMMP1L"       "HBP1"        
## [1109] "CCDC58"       "PPP4R3B"      "TASOR2"       "ZNF721"      
## [1113] "LNX1"         "PKIA-AS1"     "VEZT"         "ACTR6"       
## [1117] "SLC35A3"      "DOP1A"        "CEPT1"        "GNPDA2"      
## [1121] "ZBTB41"       "THADA"        "C5orf34"      "MTX3"        
## [1125] "ZNF484"       "AC084824.2"   "RPS27AP16"    "ZNF550"      
## [1129] "ZNF548"       "PEX3"         "MMS22L"       "RESF1"       
## [1133] "TSGA10"       "ETAA1"        "IFT88"        "NBAS"        
## [1137] "TIFA"         "AL160287.1"   "FBXO48"       "THUMPD3-AS1" 
## [1141] "ZNF529"       "SINHCAFP2"    "AL592293.2"   "FNDC9"       
## [1145] "RPL39P3"      "SLC9B1"       "PYROXD1"      "MIR4796"     
## [1149] "OARD1"        "PPM1K"        "RPL23AP67"    "ZNF268"      
## [1153] "ZNF737"       "MUC16"        "AP000787.1"   "U2SURP"      
## [1157] "SNRPGP4"      "ZFP82"        "ARL6"         "AC055822.1"  
## [1161] "KIAA0586"     "ZNF880"       "ZNF136"       "FBXL13"      
## [1165] "TAS2R46"      "RPS23P8"      "PNO1"         "AC010168.2"  
## [1169] "SAXO2"        "PAICS"        "SNRPGP12"     "TMEM67"      
## [1173] "FNBP1P1"      "TAS2R14"      "HAUS3"        "C12orf60"    
## [1177] "NPM1P39"      "ANKRD36"      "PSIP1"        "OSGEPL1"     
## [1181] "AC096921.2"   "C4orf17"      "AL445523.1"   "ZNF654"      
## [1185] "NDUFA5"       "AC092747.4"   "ZDBF2"        "TXLNG"       
## [1189] "HNRNPC"       "DPY19L2P2"    "AC090571.1"   "GCC2"        
## [1193] "KIZ"          "AL035456.1"   "PM20D2"       "DEFB131B"    
## [1197] "TUT4"         "RDH14"        "RPS27A"       "SUSD5"       
## [1201] "RPL21"        "HELQ"         "PAIP2B"       "ZRANB3"      
## [1205] "PREPL"        "ZNF43"        "TRPC1"        "THUMPD1"     
## [1209] "PUS7L"        "ZNF773"       "ZEB1-AS1"     "VPS13A"      
## [1213] "PTPDC1"       "ZNF626"       "SUZ12P1"      "ZNF770"      
## [1217] "SDAD1"        "AL137139.2"   "OMA1"         "LATS1"       
## [1221] "RPL41"        "TM2D3"        "NOL11"        "HNRNPH1"     
## [1225] "AL121583.1"   "ERGIC2"       "DIS3"         "NUBPL"       
## [1229] "CUBN"         "CLEC2D"       "ZNRD1ASP"     "GPALPP1"     
## [1233] "AL353795.1"   "FARP1"        "UBE2N"        "ASNSD1"      
## [1237] "FOXP1"        "ZNF506"       "HMGN1"        "PGM2L1"      
## [1241] "CLN5"         "ZNF460-AS1"   "RPS3AP6"      "BNIP3"       
## [1245] "RPS3AP26"     "ITGB3BP"      "TRMO"         "ZNF84"       
## [1249] "RELCH"        "AC092640.1"   "AC009487.2"   "DDX50P1"     
## [1253] "AL845472.2"   "AC104806.2"   "POT1"         "SLC3A1"      
## [1257] "TUBE1"        "SNHG14"       "POLR2M"       "ORC5"        
## [1261] "REV3L"        "PDE5A"        "TTC3"         "AC110611.1"  
## [1265] "ZNF431"       "TEX10"        "ARHGAP15"     "ZNF181"      
## [1269] "AL512308.1"   "ARRDC3"       "NPM1P24"      "RGMB"        
## [1273] "AP000766.1"   "CEP120"       "EIF4E"        "NAP1L4P3"    
## [1277] "ZSCAN30"      "RPS20P10"     "FRA10AC1"     "MIGA1"       
## [1281] "KIF20B"       "PKIA"         "THNSL1"       "DZIP3"       
## [1285] "TARS3"        "MTBP"         "AC023906.4"   "ZNF141"      
## [1289] "COA1"         "GRIN3A"       "RPL21P75"     "TGS1"        
## [1293] "PSMA8"        "ZNF708"       "PMPCB"        "AC243919.1"  
## [1297] "TTC14"        "PACRGL"       "AC138150.1"   "ORC2"        
## [1301] "AC016957.1"   "AC133644.3"   "AC092656.1"   "AC005912.1"  
## [1305] "TBCA"         "SNORD11"      "ZNF138"       "RNA5SP355"   
## [1309] "LRPPRC"       "ZNF121"       "NPM1P6"       "RBM26"       
## [1313] "G2E3"         "ANKRD18EP"    "RSBN1"        "AC008507.2"  
## [1317] "CLYBL-AS2"    "TRPC5"        "ZNF546"       "MTREX"       
## [1321] "BBS2"         "SIRT1"        "IFT22"        "TRMT11"      
## [1325] "MRPL50"       "EIF4A2"       "CCDC141"      "BRWD1"       
## [1329] "CHTOP"        "ZNF248"       "NAP1L1P1"     "IMMP2L"      
## [1333] "USP37"        "ZMAT1"        "AC004908.1"   "SCYL3"       
## [1337] "ZNF229"       "RASA1"        "USP51"        "HBS1L"       
## [1341] "CEBPZ"        "GCSAM"        "RALGAPA1"     "PMS2P11"     
## [1345] "NPM1"         "RAPGEF6"      "PABPC1P7"     "AC006539.2"  
## [1349] "RPL12P8"      "CCDC18-AS1"   "ZNF354B"      "CCDC138"     
## [1353] "C11orf58"     "AL023584.2"   "RBL1"         "NAP1L1"      
## [1357] "ELP2"         "CEP97"        "THAP5"        "PPAT"        
## [1361] "UTP15"        "CENPCP1"      "AC026356.2"   "SSB"         
## [1365] "AL049828.1"   "ZNF891"       "CASD1"        "EIF1AX"      
## [1369] "PPWD1"        "NIT2"         "ZNF486"       "XPA"         
## [1373] "AL365361.1"   "SINHCAF"      "TBC1D32"      "WDR75"       
## [1377] "THAP6"        "RIC3"         "EPB41L5"      "TRIM23"      
## [1381] "ZBTB20-AS1"   "TUBD1"        "NBPF11"       "EPC1"        
## [1385] "CWF19L2"      "ICE2"         "TMTC3"        "AC124016.3"  
## [1389] "ARHGEF35-AS1" "RNASEH2B"     "AL356599.1"   "MTAP"        
## [1393] "TTN"          "AP5M1"        "AC027801.5"   "MTERF3"      
## [1397] "NAA15"        "ESCO1"        "NOC3L"        "RGPD2"       
## [1401] "AKAP11"       "SGPP2"        "ATL2"         "CEP135"      
## [1405] "OTUD3"        "TTC23L"       "ZNF681"       "PPP4R3A"     
## [1409] "KIAA1586"     "UTP20"        "METTL4"       "DCUN1D4"     
## [1413] "ANGEL2"       "AP000560.1"   "WASHC3"       "AC118549.1"  
## [1417] "PTCD3"        "HSD17B7P2"    "SRSF8"        "ZNF680"      
## [1421] "C18orf25"     "C12orf29"     "USP45"        "HECTD2"      
## [1425] "IFT80"        "NBPF8"        "DDX18"        "AC092279.1"  
## [1429] "ZNF658"       "LIN9"         "ZXDA"         "WDR33"       
## [1433] "LYRM7"        "THAP5P1"      "NOP58"        "ZNF675"      
## [1437] "ZNF283"       "UTP23"        "ZNF273"       "SLC16A1-AS1" 
## [1441] "ZNF480"       "AC011939.1"   "AL034379.1"   "AL096803.2"  
## [1445] "ZNF717"       "TMEM161B"     "AC068700.1"   "GPR89B"      
## [1449] "CEP44"        "AC006971.1"   "TBC1D15"      "ZMYM2"       
## [1453] "BRIX1"        "DYNLT3"       "EEF1AKMT2"    "MICOS10"     
## [1457] "ORC4"         "DMTF1"        "NT5DC1"       "DNAJC16"     
## [1461] "ZRANB2"       "MTHFD1"       "AP002433.2"   "CHCHD7"      
## [1465] "TFAM"         "RPP30"        "TRMT13"       "NR1D2"       
## [1469] "TNKS"         "FOXO1"        "AL158163.1"   "GPBP1"       
## [1473] "SETDB2"       "TMEM161B-AS1" "SMAD4"        "SCAI"        
## [1477] "SMCHD1"       "ZNF430"       "ACAT1"        "APPBP2"      
## [1481] "RFPL3S"       "FARSB"        "AC093157.1"   "FANCM"       
## [1485] "TBCK"         "EXOSC3"       "SENP7"        "GTPBP10"     
## [1489] "KPNA5"        "FBXL4"        "FASTKD2"      "RPS3A"       
## [1493] "FBXL3"        "CNOT7"        "OTUD6B-AS1"   "UGCG"        
## [1497] "MTO1"         "HNRNPA1"      "GORAB"        "RNF145"      
## [1501] "ZNF140"       "ZNF189"       "ZXDB"         "AF129075.2"  
## [1505] "ZNF292"       "EFCAB7"       "AP000648.4"   "ARHGAP5"     
## [1509] "GNPNAT1"      "COG3"         "CLK4"         "NBPF15"      
## [1513] "EML4"         "KRR1"         "RAD51B"       "AC009318.1"  
## [1517] "AL360020.1"   "XPO4"         "SEPSECS"      "RALGAPA1P1"  
## [1521] "FAM133B"      "PIBF1"        "SLC4A7"       "LINC01184"   
## [1525] "BBIP1"        "ORC3"         "TRNT1"        "TTC3P1"      
## [1529] "LSM8"         "DLG1"         "AC010978.1"   "PDE7A"       
## [1533] "PGM3"         "GCFC2"        "MFSD8"        "PHF10"       
## [1537] "AC009505.1"   "N4BP2L2"      "TRDMT1"       "CBWD5"

Signature positive et négative

Boxplot Signature

##  [1]  0.14273465  0.26271412  0.05685542  0.68040999 -0.27542062 -0.16233059
##  [7] -0.14014183  0.07166735  0.65684208  0.05871322  0.10823833  1.01115307
## [13]  0.39775358  0.39564771  0.52006762  0.75781704  0.89657045  1.62639068
## [19]  1.58084750  1.00213975  1.87319587  1.25441882  1.33353490  1.13024242
## [25]  1.25613473  0.61202476  1.31601763  1.20989785  0.66127161  0.43685941
## [31]  0.81991780  0.73252852  1.30205554  0.14628083  0.41972041  0.93221003
## [37]  0.76327930  0.56898737  0.30157369  0.77436246  0.67623759  1.49033492
## [43]  1.51078926  0.93240551  1.39697131  1.77787999  1.34391404  1.11195977
## [49]  1.12293838  0.94825412  0.78224153  1.28226722  0.08589029  1.05531674
## [55]  1.02441460 -0.04262600  0.89137586  1.38359913  1.28677976  1.05921510
## [61]  0.24671590  0.49073932  0.19679063  0.02418572 -0.12039191  1.00648941
## [67]  0.49887460  0.96531226  0.51232388  1.29508065  0.15738043 -0.40291664
## [73]  0.21347196  0.11412455 -0.13699927  0.55381313  0.18929242 -0.09723826
## [79]  0.30524985  0.03307520  0.14837193
##  [1]  1.30448020  1.79290910  0.65695306  1.33386968  0.55482157  1.92806788
##  [7]  1.49564995  0.95720429  0.63048351  0.69886139  1.48497062  1.46405852
## [13]  1.26722720  0.43466894  0.60799967  0.75031927  0.73785088  0.70454865
## [19]  0.50136108  0.63811481  1.24522875  1.42563561  1.65175589  1.80842152
## [25]  0.85131727  0.23204062  1.14625257  1.65739924 -0.01989412  0.22996686
## [31] -0.45892847  0.29475555
##  [1] -0.14621791  0.46841162 -0.02094706  0.71970386  0.31114258  2.09910755
##  [7]  1.97796308  1.48876568  2.22388682  1.80067440  1.17021042  1.26016730
## [13]  0.71602154  1.38101304  0.80990762  0.27474053  0.68552638  0.54534899
## [19]  1.24203292  0.11076659  0.33338108  1.06464809  0.69884283  1.75451004
## [25]  1.73936500  1.16078856  1.66038156  2.07052323  1.36694632
##  [1] 1.1625673 0.6268884 1.6958864 1.6926948 1.2191284 0.8029794 1.9638917
##  [8] 2.0506117 1.0542333 0.7809311 2.0306598 2.0025564 3.2563765 3.1331870
## [15] 2.7423316 3.1445060 1.9667543 1.2221513 1.6597651 2.8811835

Boxplot Total All

### Boxplot Total AML

Boxplot Total Normal_BM

Boxplot Total Normal_PB

Venn diagram

## [1] "ACLY"    "NUP93"   "SEC61A1" "N4BP2L2" "CENPCP1"

Signature positive

Boxplot Signature

##  [1] "ACLY"       "NUP93"      "UBE2I"      "PSMC3"      "AL356000.1"
##  [6] "MDH2"       "PPM1G"      "CYC1"       "SEC61A1"    "POLDIP2"   
## [11] "CCT5P1"     "COPG1"      "ICMT"       "MRPS34"     "PIGS"      
## [16] "CHID1"
##  [1] "ACLY"       "ACLY"       "NUP93"      "NME2P1"     "UBE2I"     
##  [6] "MYL6P5"     "COX6A1P2"   "ICMT"       "PSMD13"     "ATP5PBP6"  
## [11] "DOLK"       "RPP25L"     "AC012066.1" "PPIAP31"    "PMVK"      
## [16] "ATP5ME"     "LAMTOR2"    "DCAF7"      "AC015871.1" "MRPL34"    
## [21] "RPS27P27"   "PRDX5"      "GAPDHP1"    "HSPA8P7"    "UQCR11"    
## [26] "POTEE"      "PPP1CA"     "CHCHD2P2"   "GSS"        "COX8A"     
## [31] "CCT3"       "BCAP31"     "SRP14"      "MRPL11"     "COX17P1"   
## [36] "UQCR10"     "PPIAP22"    "TRMT112"    "TPI1"       "BUB3P1"    
## [41] "SEC61A1"    "SUMF2"      "TTC38"      "TNFAIP8L2"  "PPIA"      
## [46] "MYL6P3"     "PSMA7"      "PFN1P1"     "CDCA5"      "EDEM2"
##   [1] "ACLY"       "ANAPC5"     "TIMM50"     "MCM2"       "SMARCAL1"  
##   [6] "ILF3"       "STOML2"     "NUP210"     "B4GALT2"    "GATB"      
##  [11] "POLDIP2"    "MPST"       "TTLL12"     "WDR5"       "AC005102.1"
##  [16] "AC092042.2" "EIF3B"      "ALYREF"     "TADA3"      "PIGS"      
##  [21] "FBLN2"      "GALE"       "MCM7"       "BOP1"       "LETM1"     
##  [26] "AC098591.2" "SURF4"      "CCT5P1"     "DAG1"       "RBM14"     
##  [31] "ALDH4A1"    "APEH"       "YIF1B"      "PSMC3"      "COQ4"      
##  [36] "CENPX"      "CYC1"       "TYK2"       "AC025161.1" "H1-5"      
##  [41] "CCT3"       "MTHFD1P1"   "ACADVL"     "SIGMAR1"    "MED24"     
##  [46] "YBX1P6"     "MRPS7"      "UQCRC1"     "SLC35A4"    "PMPCA"     
##  [51] "BOLA2P1"    "ACOT7"      "DUS1L"      "TNPO2"      "CLN6"      
##  [56] "STK25"      "NUP93"      "IDH2"       "IRAK1"      "GCAT"      
##  [61] "RPS21"      "DDX39A"     "RUSC1"      "POLD2"      "CENPUP1"   
##  [66] "NDUFB10"    "MCM5"       "NELFCD"     "PGP"        "PRDX4"     
##  [71] "AAAS"       "AL356000.1" "FARSA"      "PHKG2"      "TST"       
##  [76] "TXN2"       "AUP1"       "SMG5"       "POLE"       "KARS1"     
##  [81] "RPN2"       "PMP22"      "E2F1"       "CHID1"      "XRCC6P3"   
##  [86] "MRPL54"     "PLOD3"      "GCN1"       "INTS11"     "NECTIN1"   
##  [91] "KLHDC3"     "PTBP1"      "AC013244.1" "FCGRT"      "NDUFA3"    
##  [96] "AC011753.3" "GCDH"       "FARS2"      "MT-TL1"     "RNPS1"     
## [101] "DAD1"       "MORN2"      "OGDH"       "HNRNPA1P28" "AL161636.2"
## [106] "ACTBP2"     "CLPTM1"     "S100A6"     "Z93019.1"   "ARPC4"     
## [111] "PRDX2P2"    "GPS1"       "HMGB3P8"    "C11orf24"   "DHRS3"     
## [116] "AL031229.1" "DDX41"      "AC138932.4" "DNM2"       "RPL14P3"   
## [121] "RAB5C"      "P4HB"       "EFTUD2"     "COX5B"      "ELAC2"     
## [126] "RANP5"      "TK1"        "PREB"       "CARM1"      "AC079328.1"
## [131] "SF3B5"      "TMCO6"      "TALDO1"     "ERAL1"      "MRPL4"     
## [136] "EIF4G1"     "GUSB"       "NDUFS6"     "RFXANK"     "NDUFB9P2"  
## [141] "TUFM"       "LRPAP1"     "AL357134.1" "PRPF19"     "RNASEH2C"  
## [146] "IPO5"       "PPM1G"      "DCXR"       "ACTG1P14"   "PTPA"      
## [151] "NDUFB4"     "GATAD2A"    "AC026410.1" "PLOD1"      "TMEM147"   
## [156] "NPM1P4"     "FLOT2"      "MRPS34"     "SNRPA"      "PPIAP71"   
## [161] "LAGE3"      "AHCYP4"     "TMEM109"    "VPS25"      "AC133435.1"
## [166] "CDV3P1"     "DDX49"      "ATP5PBP7"   "NDUFB11P1"  "RITA1"     
## [171] "CYCSP51"    "MRPS2"      "DNTTIP1"    "ARAF"       "TPM3P4"    
## [176] "AC107983.1" "MDH2"       "YIF1A"      "NDUFS5P5"   "ARMC6"     
## [181] "TMEM141"    "THAP4"      "NPM1P9"     "AL358934.1" "SLC5A6"    
## [186] "UBA52P3"    "PRELID1P1"  "SRRT"       "DRAP1"      "EBP"       
## [191] "AC005262.1" "LDB1"       "AC074134.1" "MYDGF"      "NCAPH2"    
## [196] "AL021877.1" "RPL19P21"   "POLR3H"     "TYMSP2"     "MORF4L1P3" 
## [201] "CLUHP6"     "TPCN1"      "NELFE"      "FECHP1"     "RPS4XP9"   
## [206] "BTF3P13"    "NHP2P2"     "ABCF3"      "RPL7P20"    "PTBP1P"    
## [211] "FAM234A"    "MYL6P4"     "ARF1"       "SEC24C"     "SHARPIN"   
## [216] "RPL12P13"   "SLC25A11"   "PPIAP65"    "RPL4P1"     "GTF3C5"    
## [221] "RPL7P36"    "RPUSD3"     "AC010376.1" "PFN1P9"     "PAICSP2"   
## [226] "CENPT"      "RPL8P2"     "HPS1"       "AC008799.1" "POLR2L"    
## [231] "ACTBP8"     "AC090312.2" "AL021407.2" "CERS2"      "CHMP1A"    
## [236] "GET3"       "UBA1"       "MTHFD1"     "THOP1"      "FTSJ1"     
## [241] "RPL7P13"    "GRHPR"      "AC016734.1" "FP565171.1" "BAG6"      
## [246] "PAICSP3"    "SYNGR2"     "NME4"       "AL451050.1" "CNN2P10"   
## [251] "COPG1"      "ATP5MC1"    "AF241726.1" "MAZ"        "BTF3L4P1"  
## [256] "AC097713.2" "DHX16"      "ACTG1P19"   "ELOB"       "CAPN1"     
## [261] "COLGALT1"   "POLR2I"     "AC074281.1" "HDLBP"      "USB1"      
## [266] "MTCO1P40"   "WBP11P1"    "HPS6"       "FOXRED1"    "AC012671.1"
## [271] "EIF5AP4"    "CRAT"       "RANGAP1"    "C19orf48"   "MRPL28"    
## [276] "SEC61A1"    "EMD"        "NDUFS5"     "SUMO2P6"    "CPSF4"     
## [281] "AP005431.2" "EBNA1BP2"   "ATP5MC1P6"
##    [1] "ACLY"       "ACLY"       "CTSD"       "ARPC4"      "COMMD5"    
##    [6] "USB1"       "SLC25A35"   "CDKN2D"     "LAMP1"      "RPS6KA1"   
##   [11] "CAP1"       "XKR8"       "RRBP1"      "COPG1"      "CAPNS1"    
##   [16] "DAG1"       "IFITM3"     "REEP4"      "FURIN"      "PLOD1"     
##   [21] "CBX6"       "AP2A1"      "CFL1"       "PIGS"       "G6PD"      
##   [26] "CLIC1"      "GADD45B"    "WDR45P1"    "SLC35F6"    "ITGB2"     
##   [31] "CDIP1"      "CHFR"       "ARHGAP30"   "TLN1"       "C15orf39"  
##   [36] "ADAM8"      "ADAP1"      "BCAP31"     "ACTBP1"     "MYO1F"     
##   [41] "POLR2L"     "EIF6"       "ACTR1A"     "ZNHIT1"     "HCLS1"     
##   [46] "P4HB"       "TRAPPC1"    "BAIAP2"     "MSNP1"      "MAPKAPK2"  
##   [51] "CCDC69"     "FHOD1"      "MRPL28"     "MGAT1"      "PREX1"     
##   [56] "NAA60"      "GID8"       "ELF4"       "TSPOAP1"    "SLC1A5"    
##   [61] "TPM3P8"     "LGALS1"     "RITA1"      "PLCB2"      "TMEM214"   
##   [66] "BRD3"       "CAP1P2"     "TGFB1"      "ACTN4"      "GAK"       
##   [71] "ACTN4P1"    "H6PD"       "WBP1L"      "NECTIN1"    "AAMP"      
##   [76] "CYB561D2"   "VCP"        "COX8A"      "IDH2"       "CDIPT"     
##   [81] "MYL6P5"     "EIF4G1"     "PLEKHM1"    "TNRC18"     "ATP6AP1"   
##   [86] "VPS16"      "MFSD10"     "PTPN18"     "MARS1"      "LMAN2"     
##   [91] "NARF"       "TUBB4B"     "TCIRG1"     "GANAB"      "TNFSF12"   
##   [96] "EFHD2"      "TMED9"      "TYK2"       "MOB3A"      "SURF4"     
##  [101] "BSG"        "ITPK1"      "GBA"        "KLF13"      "ARHGAP1"   
##  [106] "GSTP1"      "TLE4"       "EEF1AKMT4"  "CTDSP1"     "ARHGAP27"  
##  [111] "YIPF3"      "GSK3A"      "ADCY7"      "UBE2I"      "RCC2P6"    
##  [116] "INCENP"     "FERMT3"     "STK40"      "KIAA0895L"  "GNAI2"     
##  [121] "RHOG"       "PRDX5"      "ZDHHC12"    "SLC9A1"     "PPP1R18"   
##  [126] "ARAP1"      "AUP1"       "MAP2K3"     "RAB35"      "RAB8A"     
##  [131] "NFKBIB"     "SLC25A11"   "GNB1"       "AC026462.1" "SDF2L1"    
##  [136] "KEAP1"      "AC093700.2" "TESC"       "MAST2"      "LIMK1"     
##  [141] "TST"        "FLOT1"      "ATP6V0D1"   "HYAL2"      "OS9"       
##  [146] "MAST3"      "MAP3K11"    "SNAPC2"     "KCNAB2"     "P3H1"      
##  [151] "DOK1"       "PDIA4"      "SHC1"       "PSMD2"      "CD151"     
##  [156] "COASY"      "EFNB1"      "PPP1R12C"   "CTDNEP1"    "PPCDC"     
##  [161] "HDGFL2"     "POLDIP3"    "OSBPL5"     "ENG"        "SEC16A"    
##  [166] "COPS7A"     "CDK2AP2"    "AC026877.1" "CANT1"      "NLRX1"     
##  [171] "CDC37"      "TPD52L2"    "AC023157.1" "SIRT2"      "CFL1P2"    
##  [176] "EDEM2"      "FBXL19"     "DNAJC5"     "CISD3"      "IMPDH1"    
##  [181] "PDLIM2"     "ZFP36"      "TBC1D10B"   "SNAI3"      "MEF2D"     
##  [186] "DNM2"       "ACADVL"     "FHL3"       "SYNGR1"     "AL159141.1"
##  [191] "RAB5C"      "NBEAL2"     "TNFRSF1B"   "MAD2L2"     "TOLLIP"    
##  [196] "PTGES2"     "CATSPER1"   "JOSD2"      "FLNA"       "ABHD4"     
##  [201] "SLC27A3"    "ARPC2"      "RIC8A"      "CALHM2"     "ZMIZ1"     
##  [206] "DGKZP1"     "INPPL1"     "ABR"        "PYCARD"     "NACC1"     
##  [211] "GUSB"       "SNX33"      "HSD17B10"   "WDR1"       "BST2"      
##  [216] "PISD"       "CTNS"       "BORCS8"     "MAML1"      "SSH3"      
##  [221] "TSPAN17"    "PIP5K1C"    "SFXN5"      "SH3BGRL3"   "LBX2-AS1"  
##  [226] "WAS"        "SCRIB"      "IL27"       "APOBR"      "DGKZ"      
##  [231] "MMP25"      "COMT"       "SLC35A4"    "ATG13"      "AC138932.4"
##  [236] "YIF1B"      "VPS11"      "DMAC2"      "WDTC1"      "RTF2"      
##  [241] "GTF3C1"     "PLCB3"      "RTL8C"      "GHDC"       "ANXA2P3"   
##  [246] "EMP3"       "ZNF213"     "SNX17"      "ZNF362"     "ELOVL1"    
##  [251] "TMEM184B"   "PTPA"       "MFN2"       "RAB5CP2"    "PRKACA"    
##  [256] "TM9SF4"     "TANGO2"     "CD2BP2"     "IFITM2"     "ACP2"      
##  [261] "SLC27A4"    "STK11IP"    "PLXND1"     "POTEF"      "NUCB1"     
##  [266] "PSMA7"      "OSBPL2"     "EIF3B"      "ZNF282"     "AKT1"      
##  [271] "DDX41"      "SCAMP4"     "ADAM15"     "TMEM109"    "CCDC159"   
##  [276] "HPS6"       "COLGALT1"   "MAPKAPK3"   "G6PC3"      "COPE"      
##  [281] "CAPN1"      "DCTN3"      "PLOD3"      "FAM32A"     "MOGS"      
##  [286] "NOC4L"      "TWF2"       "AC006970.1" "SPSB2"      "PSMB6"     
##  [291] "MYO9B"      "UNC13D"     "LSP1"       "TUBGCP2"    "GMIP"      
##  [296] "PSAP"       "GPKOW"      "PEPD"       "PPP1R26"    "PSMB2"     
##  [301] "AGTRAP"     "ZNF646"     "ANTKMT"     "UNC45A"     "BLOC1S1"   
##  [306] "SCNM1"      "ACTBP9"     "AP2A2"      "ABHD12"     "TMEM250"   
##  [311] "LMNB2"      "ADCY9"      "CSNK2A3"    "UNC119"     "MFSD5"     
##  [316] "MED29"      "LAMTOR2"    "ACTB"       "IFI35"      "AP3D1"     
##  [321] "SHKBP1"     "CSNK1D"     "MARCHF2"    "PSMD4"      "FMNL1"     
##  [326] "CTSA"       "TPI1P1"     "GLYR1"      "GPAA1"      "AL354989.2"
##  [331] "AC016734.1" "PBX2"       "SF3B2"      "CAMKK2"     "GBA2"      
##  [336] "KATNB1"     "ITGAX"      "FIBP"       "PSME2"      "HCFC1R1"   
##  [341] "AC023232.1" "CHMP2A"     "CDK5"       "PRELID1"    "ICMT"      
##  [346] "SLC27A1"    "HTT"        "SH2D3C"     "DEDD2"      "EXOSC4"    
##  [351] "DOK2"       "APEX2"      "RAB7A"      "PEAK3"      "DDOST"     
##  [356] "MYDGF"      "ANAPC2"     "DOT1L"      "TRIOBP"     "LDHAP5"    
##  [361] "SLC29A3"    "ZDHHC3"     "GPR35"      "H2AX"       "ARF1"      
##  [366] "GRAMD4"     "RXRA"       "PPM1F"      "ULK1"       "TMEM115"   
##  [371] "FBXO6"      "VAV1"       "GNPTG"      "LDLR"       "EFTUD2"    
##  [376] "AL121723.1" "NCOA6"      "ISOC2"      "PSME3"      "MCRIP1"    
##  [381] "PSMC4"      "NOTCH1"     "RAB1B"      "MSRB1"      "NKIRAS2"   
##  [386] "BABAM1"     "TXLNA"      "CCDC88B"    "CERS2"      "MRPS34"    
##  [391] "ARL8A"      "GAPDH"      "POTEE"      "NDUFS8"     "FAM50A"    
##  [396] "CHMP1A"     "ADRM1"      "ZYX"        "TYROBP"     "TRABD"     
##  [401] "AP2M1"      "Z97180.1"   "SDF4"       "LAMTOR1"    "MBD3"      
##  [406] "HNRNPAB"    "MRGBP"      "KLF16"      "ANAPC11"    "ESRRA"     
##  [411] "RNF44"      "TMEM11"     "UBN1"       "SLC38A10"   "CD99L2"    
##  [416] "GAPDHP60"   "UBE2L6"     "EHD1"       "COMMD4"     "PRELID1P1" 
##  [421] "ITPRIP"     "HRAS"       "FBXW5"      "PLEKHO2"    "SEC61A1"   
##  [426] "BRPF1"      "PGAP6"      "NRROS"      "TOP3A"      "HYOU1"     
##  [431] "SSH1"       "TMEM164"    "WDR13"      "COQ8A"      "PORCN"     
##  [436] "GRK2"       "ATP6V1F"    "PRKCSH"     "RAC2"       "ZNRD2"     
##  [441] "CLPTM1L"    "MARK4"      "IPO13"      "PSMB3"      "RTL8A"     
##  [446] "FAM234A"    "PNPLA6"     "OTUB1"      "HSPA7"      "PLEKHM1P1" 
##  [451] "PSMC3"      "FRMD8"      "RGS19"      "PLD3"       "EIF4A1P4"  
##  [456] "CDK9"       "FAM214B"    "EHBP1L1"    "RNF166"     "FLYWCH2"   
##  [461] "GYS1"       "IDH3G"      "TUBA1B"     "BLVRB"      "RNH1"      
##  [466] "AKT1S1"     "MPV17L2"    "IGF2R"      "TMEM104"    "C19orf25"  
##  [471] "ANKRD13D"   "RELA"       "TAPBPL"     "NUP93"      "NCSTN"     
##  [476] "GALNT6"     "SLC26A6"    "MSN"        "KSR1"       "EMC8"      
##  [481] "DNAJB12"    "RIPK3"      "PHC2"       "ARFGAP1"    "MAPK7"     
##  [486] "PTBP1"      "CYC1"       "MAP2K7"     "CAMTA2"     "STARD3"    
##  [491] "TIMP1"      "HPS1"       "SAT2"       "CREB3"      "PITPNM1"   
##  [496] "TRIM11"     "ADGRE5"     "PTTG1IP"    "SLC4A2"     "PLIN3"     
##  [501] "STX4"       "NCOR2"      "DHX8"       "DPYSL2"     "CSNK2B"    
##  [506] "PHPT1"      "HLA-B"      "PUF60"      "GRN"        "LRPAP1"    
##  [511] "CLPTM1"     "ANXA2P1"    "TBC1D9B"    "MIDN"       "MVP"       
##  [516] "ATP6V0CP3"  "PSTPIP1"    "MARK2"      "HIVEP3"     "HDLBP"     
##  [521] "AMPD2"      "HNRNPKP2"   "RALBP1"     "BATF"       "PIGQ"      
##  [526] "DDX49"      "CCND3P1"    "FAM89B"     "CORO1A"     "ZNF710"    
##  [531] "SLC52A2"    "RNPEP"      "ZNF787"     "TTC31"      "KDELR1"    
##  [536] "SHISA5"     "LYPLA2"     "PREB"       "AP2S1"      "THEMIS2"   
##  [541] "HIPK2"      "PPP4C"      "TBCB"       "AP002414.4" "SRPRA"     
##  [546] "ENO1"       "PGP"        "TPI1"       "TMBIM1"     "VPS53"     
##  [551] "PYGB"       "MED11"      "CD300LB"    "STX18"      "MRPS12"    
##  [556] "PSMD13"     "CTBP2P8"    "RNPEPL1"    "NAPA"       "NUP62"     
##  [561] "KIAA2013"   "TEDC1"      "RABL6"      "DECR2"      "GNB2"      
##  [566] "CNPY3"      "IFI27L2"    "GLMP"       "MDH2"       "PDE6G"     
##  [571] "ISY1"       "TESK1"      "STXBP2"     "SCAMP2"     "FBP1"      
##  [576] "RHOC"       "CASC3"      "CD300C"     "AL596087.1" "LRRC8A"    
##  [581] "UBE2Q1"     "DDRGK1"     "CERCAM"     "ZSWIM8"     "CCAR2"     
##  [586] "LASP1"      "POMGNT2"    "ABCF2"      "MBOAT7"     "UBE2J2"    
##  [591] "LSM10"      "LCP1"       "UROD"       "SCYL1"      "HK1"       
##  [596] "PARP10"     "AL080243.2" "HMOX1"      "PPP1CA"     "SP2"       
##  [601] "AC020629.1" "WDR25"      "TUBG1"      "NDUFV1"     "CPAMD8"    
##  [606] "TOR2A"      "GATAD2A"    "ATG2A"      "PTPN9"      "SHARPIN"   
##  [611] "TMEM53"     "USP4"       "SLC38A7"    "CARD19"     "E2F4"      
##  [616] "NADK"       "DYSF"       "PTPN6"      "RBM42"      "SNX32"     
##  [621] "ATP5F1B"    "CTRC"       "PPP6R1"     "ELOF1"      "MCRS1"     
##  [626] "SIPA1"      "CCT5P1"     "DUS1L"      "TNK2-AS1"   "VASP"      
##  [631] "STAT3"      "CRAT"       "MGRN1"      "PIK3R5"     "STK11"     
##  [636] "PDE4A"      "STEAP3"     "MIIP"       "RUVBL2"     "TMEM91"    
##  [641] "CCDC12"     "GET3"       "ZNF598"     "U2AF2"      "RPUSD3"    
##  [646] "MYO1G"      "ABCD1"      "MAP2K1P1"   "UBE2D3P2"   "TK2"       
##  [651] "ZC3H18"     "NECAB3"     "TRPV2"      "CHID1"      "UQCRC1"    
##  [656] "CNP"        "RBCK1"      "SLC10A3"    "ATP13A2"    "GSS"       
##  [661] "DGAT1"      "MLX"        "TECPR2"     "TMEM161A"   "NPLOC4"    
##  [666] "PRKCD"      "TXN2"       "IL27RA"     "ZNF316"     "CST3"      
##  [671] "EIF4A1P7"   "PKN1"       "IP6K1"      "HNRNPUL1"   "SMARCA4"   
##  [676] "LSP1P3"     "NCLN"       "IQCE"       "ZBTB45"     "SLC45A4"   
##  [681] "ALAS1"      "RPN2"       "LRP10"      "ISG15"      "APOA2"     
##  [686] "CTNNBIP1"   "FLII"       "SZRD1"      "CUEDC2"     "ATOX1"     
##  [691] "ICAM1"      "ACTBP8"     "NRBP1"      "RPS19BP1"   "ADGRA2"    
##  [696] "TMEM39B"    "TRIM8"      "LRRC41"     "STUB1"      "ZBED1"     
##  [701] "ZNF384"     "SLC6A6"     "GAA"        "SAMD4B"     "VPS28"     
##  [706] "EIF2AK1"    "PSMB4"      "GALNT2"     "RNF167"     "COPZ1"     
##  [711] "RNF123"     "C7orf26"    "PHRF1"      "RABGGTA"    "CRELD2"    
##  [716] "CMTM1"      "CLTB"       "SCAMP3"     "DYNLL1P2"   "MAP1S"     
##  [721] "UBA7"       "SEC24C"     "CAVIN2"     "SGPL1"      "PFN1P1"    
##  [726] "MAP3K6"     "TICAM1"     "ZZEF1"      "FOXJ2"      "MOSPD3"    
##  [731] "TSPO"       "ECHS1"      "GAPDHP65"   "SIGLEC9"    "IL15RA"    
##  [736] "MVB12A"     "SRA1"       "SMIM12"     "ZBTB7B"     "DPP9"      
##  [741] "SF3B4"      "KCNH3"      "FBXL18"     "GLIPR2"     "SASH3"     
##  [746] "HGS"        "KMT2D"      "ARRDC1"     "AC087499.4" "CYB5R3"    
##  [751] "TMEM205"    "TMEM127"    "RENBP"      "SDHB"       "GSDMD"     
##  [756] "AC116049.1" "TCF25"      "MT2P1"      "MOB2"       "MED15"     
##  [761] "ACTG1P14"   "SLC9A3R1"   "GRHPR"      "ARAP3"      "PI4KA"     
##  [766] "TALDO1"     "CHST14"     "C20orf27"   "EMC10"      "ARSG"      
##  [771] "MBD6"       "RPS6KA4"    "NSMF"       "CIC"        "PSMB10"    
##  [776] "OGDH"       "TTYH3"      "HS1BP3"     "ACTBP2"     "MAP7D1"    
##  [781] "BCKDK"      "EXTL3"      "CTBP2P4"    "CYBA"       "YIPF2"     
##  [786] "TSC2"       "PIEZO1"     "AATBC"      "ZFAND3"     "PRSS36"    
##  [791] "PTPN23"     "CMIP"       "AL356000.1" "PSME2P6"    "MLF2"      
##  [796] "CCIN"       "PHETA2"     "IVD"        "TBC1D2"     "TMEM63B"   
##  [801] "GALE"       "PDLIM7"     "RAI1"       "MPND"       "PSMD8"     
##  [806] "PACS2"      "NCKAP5L"    "ARMC7"      "GIT1"       "AL139246.5"
##  [811] "CHPF2"      "KCTD17"     "TMEM179B"   "PSME3IP1"   "MKNK2P1"   
##  [816] "ALG1L15P"   "FADS1"      "PITPNA"     "NME3"       "UQCR11"    
##  [821] "GUK1"       "MAP2K2"     "MON1B"      "ATP5F1D"    "UBE2M"     
##  [826] "TCHP"       "SPECC1"     "AC015912.3" "BCL3"       "SLAMF8"    
##  [831] "DPAGT1"     "GAPDHP63"   "CFL1P4"     "RNF40"      "WDR45"     
##  [836] "ZNF366"     "TRAF7"      "FAM78A"     "TSC22D4"    "FUOM"      
##  [841] "CYHR1"      "TMEM94"     "SYN2"       "PHF21A"     "DDX39A"    
##  [846] "PAXX"       "NMT1"       "STAT6"      "AC018413.1" "DYNLL1P3"  
##  [851] "INAFM1"     "ARSA"       "SLC2A3P2"   "C19orf47"   "ATF6B"     
##  [856] "NAGPA"      "GRK4"       "HMG20B"     "UBAC1"      "GBF1"      
##  [861] "SUGP1"      "DGCR2"      "AC020893.2" "TMEM259"    "IRAK1"     
##  [866] "GALNS"      "MAN2B2"     "DHX16"      "CLN6"       "MEA1"      
##  [871] "RPN1"       "POLDIP2"    "CTBP1"      "SPR"        "MTCH1"     
##  [876] "DNASE2"     "REPIN1"     "TAF1C"      "EIF2B1"     "HGH1"      
##  [881] "AC010997.6" "DYNC1H1"    "ECI1"       "CCDC9"      "TOR4A"     
##  [886] "ANXA2P2"    "IRF7"       "TSPAN4"     "ECH1"       "POR"       
##  [891] "LGALS2"     "MAN2A2"     "CEBPD"      "MT2A"       "ITGAM"     
##  [896] "STRN4"      "MAN1B1"     "FOXK2"      "AHRR"       "RCC2"      
##  [901] "ATG4D"      "TMEM120A"   "PDXK"       "MRTFA"      "RNF181"    
##  [906] "CENPB"      "CLTA"       "AC243960.2" "TET2"       "CNDP2"     
##  [911] "TMBIM6"     "CAPN15"     "GLULP4"     "TAOK2"      "BAG6"      
##  [916] "SRF"        "ZNF865"     "SLC35E1"    "PSME1"      "LAMTOR4"   
##  [921] "DDB1"       "MYH9"       "GPBAR1"     "ROMO1"      "VAMP5"     
##  [926] "DOHH"       "PTMS"       "CAPZB"      "TADA3"      "AC004687.1"
##  [931] "TAF4"       "NADSYN1"    "PFN1"       "COX6A1P2"   "PSMD9"     
##  [936] "BAP1"       "AATK"       "PPP1R9B"    "ZNF358"     "CABLES2"   
##  [941] "OTUD5"      "TMEM150B"   "PGD"        "ARID3B"     "TMEM129"   
##  [946] "EXOC3"      "GLULP3"     "GLT1D1"     "GTPBP2"     "FOXN3"     
##  [951] "GOLGA8K"    "PGK1P2"     "ELOB"       "LYPLA2P1"   "HCST"      
##  [956] "HSPA6"      "LST1"       "SMARCD2"    "CD300LF"    "ANXA2"     
##  [961] "M1AP"       "TAPBP"      "DNASE1L1"   "MGAT4B"     "MCOLN1"    
##  [966] "AC069366.2" "TUBB"       "AC104695.2" "TRIM26"     "RHOQP1"    
##  [971] "PGDP1"      "SRC"        "NELFB"      "B3GALT6"    "ZNF516"    
##  [976] "HCFC1"      "APEH"       "DPEP2"      "PI4K2A"     "ASL"       
##  [981] "SQSTM1"     "RAVER1"     "ATP6V0B"    "CSF1R"      "ABHD17AP1" 
##  [986] "COPS9"      "SPATA20"    "SPATA20P1"  "TNFAIP2"    "MPG"       
##  [991] "RNF217-AS1" "CEBPB"      "SH3PXD2B"   "MYD88"      "FAM174C"   
##  [996] "POLR2E"     "MAF1"       "LTBR"       "LLGL1"      "PIAS3"     
## [1001] "RAB6D"      "TMC4"       "UBL4A"      "POLR2F"     "PCBD1"     
## [1006] "CYBC1"      "TKT"        "PES1"       "MIR22HG"    "MYL6P1"    
## [1011] "OAF"        "WBP2"       "PRR14"      "PMP22"      "NUBP2"     
## [1016] "VCAN"       "PIGT"       "VPS39"      "ARID1A"     "CPVL"      
## [1021] "WDR81"      "AC079944.2" "CBX4"       "USP19"      "BAG1"      
## [1026] "UBA1"       "GPS1"       "PTBP1P"     "ACTBP7"     "ABI3"      
## [1031] "CCDC149"    "PRRC2A"     "FCGR2A"     "FAM110A"    "CMTM2"     
## [1036] "CHMP4BP1"   "ZNF467"     "COG7"       "NDUFV3"     "TEPSIN"    
## [1041] "CSF3R"      "ZSWIM4"     "UBXN6"      "ATG9A"      "AC006483.1"
## [1046] "VSIR"       "PLPPR2"     "PAK4"       "AL158201.1" "WBP1LP2"   
## [1051] "MAP3K3"     "CEACAM3"    "AC060766.5" "CCT5P2"     "CCR1"      
## [1056] "ADGRE2"     "NISCH"      "PIK3R6"     "RAB11B"     "PGLS"      
## [1061] "ANKS1A"     "PTDSS2"     "SH3GL1"     "DDX54"      "NAPRT"     
## [1066] "ACAP3"      "PCAT7"      "P2RY6"      "RPS15AP30"  "CLEC10A"   
## [1071] "GAPDHP70"   "MPST"       "C19orf38"   "PPM1M"      "PPM1G"     
## [1076] "SESN2"      "MIF4GD"     "MON1A"      "VAC14"      "ZNF628"    
## [1081] "NLRP9P1"    "AC103988.1" "ZNF746"     "CYP2S1"

Boxplot Positive All_Samples

Boxplot Positive AML

Boxplot Positive Normal_BM

Boxplot Positive Normal_PB

Venn diagram

## [1] "ACLY"    "NUP93"   "SEC61A1"

Signature négative

Boxplot Signature

##  [1] "ZNF292"  "KLHL24"  "ZNF654"  "ZNF136"  "CENPCP1" "BRWD1"   "CENPC"  
##  [8] "BRAF"    "ZBED5"   "GOSR1"   "N4BP2L2"
##  [1] "SREK1"      "H3-3A"      "RBM27"      "KPNA5"      "ATRX"      
##  [6] "MIR3611"    "BRAF"       "AP000766.1" "CTDSPL2"    "AC000123.3"
## [11] "N4BP2L2"    "CDK17"      "UBE3A"      "RTCA-AS1"   "YTHDC1"    
## [16] "MYNN"       "AC004696.1" "RLF"        "PP2D1"      "SKP1"      
## [21] "MPP5"       "KCNAB1"     "PKN2"       "EPC2"       "CRIPT"     
## [26] "CENPCP1"    "RNU6-1011P" "GOSR1"      "SLC35F5"    "ERO1B"     
## [31] "AC055764.2" "CENPC"
##   [1] "ZNF606"      "FBXW11"      "AC097376.3"  "PCMTD1"      "RBM26"      
##   [6] "HECTD2"      "AL133243.2"  "GOLGB1"      "VPS54"       "ZNF136"     
##  [11] "ZNF12"       "RYBP"        "MIR570"      "AC211476.12" "AC103724.4" 
##  [16] "LPAR6"       "AL021368.2"  "FAM111A"     "RSBN1L"      "ZBTB20-AS3" 
##  [21] "PIBF1"       "TNRC6C"      "NUMB"        "RFX3"        "CENPCP1"    
##  [26] "GON4L"       "RBBP6"       "RIC8B"       "MIR17HG"     "ZNF430"     
##  [31] "ZNF587"      "MFSD6"       "LINC00342"   "BRAF"        "UBE3A"      
##  [36] "SS18L1"      "GARS-DT"     "ATP8B1"      "CPEB3"       "ZNF493"     
##  [41] "GOSR1"       "SETX"        "EBLN3P"      "ZNF397"      "OTUD4"      
##  [46] "TTC33"       "TLK2"        "BRWD1"       "LRCH3"       "CBWD5"      
##  [51] "RPL21"       "HIF1A"       "ZNF518A"     "AL050309.1"  "RASA1"      
##  [56] "AC010186.3"  "KLHL24"      "SECISBP2L"   "NBPF14"      "ANKRD36C"   
##  [61] "AC020661.3"  "AGPS"        "NUFIP2"      "RNU11-2P"    "Z95114.3"   
##  [66] "AC009120.2"  "RC3H2"       "NEK7"        "RAB8B"       "LINC00641"  
##  [71] "ROCK1"       "DLEU2L"      "AC131206.1"  "NUDT13"      "KAT6A"      
##  [76] "HIF1AP1"     "YTHDC1"      "CHORDC1"     "AC068587.4"  "KANSL1L"    
##  [81] "BOD1L1"      "N4BP2L2"     "AC114980.1"  "SENP6"       "ARRDC3"     
##  [86] "KMT2E"       "RLIM"        "MAGOH2P"     "PPWD1"       "TNKS"       
##  [91] "SPAG9"       "FTX"         "NFYC-AS1"    "BPTF"        "ZFC3H1"     
##  [96] "RPL41"       "ELK4"        "SMAD4"       "CHD1"        "AC139769.1" 
## [101] "GABPB1"      "ZC3H6"       "MARCHF7"     "NBPF11"      "LCORL"      
## [106] "LSM8"        "GOPC"        "LRRC37A"     "CHD9"        "RBM12B"     
## [111] "NBPF15"      "TRAPPC2B"    "ATRX"        "PRPF38A"     "ZNF772"     
## [116] "ERVK13-1"    "NIFK-AS1"    "TPT1P9"      "JRKL"        "AC024075.2" 
## [121] "AC138409.2"  "AC092070.2"  "ZNF557"      "ZNF264"      "RTN4"       
## [126] "TERF1"       "GCC2"        "N4BP1"       "FAM228B"     "RAB22A"     
## [131] "ARID4B"      "TPT1-AS1"    "CENPC"       "ZNF654"      "LMBRD1"     
## [136] "FBXO11"      "ZBED5"       "ARHGAP5"     "AL353743.1"
##   [1] "P2RY10"       "EYS"          "PLCE1"        "AC093110.1"   "MZT1"        
##   [6] "WDR89"        "TAF7"         "RPL22P2"      "COL10A1"      "ZNF14"       
##  [11] "WDR36"        "CMSS1"        "ERO1B"        "EIF4A2P4"     "CEP57"       
##  [16] "SBDSP1"       "NUFIP1P1"     "NFYB"         "AL450384.2"   "CMPK1"       
##  [21] "RC3H2"        "SELENOP"      "TRMT10C"      "IMMP1L"       "HBP1"        
##  [26] "CCDC58"       "PPP4R3B"      "TASOR2"       "ZNF721"       "LNX1"        
##  [31] "PKIA-AS1"     "VEZT"         "ACTR6"        "SLC35A3"      "DOP1A"       
##  [36] "CEPT1"        "GNPDA2"       "ZBTB41"       "THADA"        "C5orf34"     
##  [41] "MTX3"         "ZNF484"       "AC084824.2"   "RPS27AP16"    "ZNF550"      
##  [46] "ZNF548"       "PEX3"         "MMS22L"       "RESF1"        "TSGA10"      
##  [51] "ETAA1"        "IFT88"        "NBAS"         "TIFA"         "AL160287.1"  
##  [56] "FBXO48"       "THUMPD3-AS1"  "ZNF529"       "SINHCAFP2"    "AL592293.2"  
##  [61] "FNDC9"        "RPL39P3"      "SLC9B1"       "PYROXD1"      "MIR4796"     
##  [66] "OARD1"        "PPM1K"        "RPL23AP67"    "ZNF268"       "ZNF737"      
##  [71] "MUC16"        "AP000787.1"   "U2SURP"       "SNRPGP4"      "ZFP82"       
##  [76] "ARL6"         "AC055822.1"   "KIAA0586"     "ZNF880"       "ZNF136"      
##  [81] "FBXL13"       "TAS2R46"      "RPS23P8"      "PNO1"         "AC010168.2"  
##  [86] "SAXO2"        "PAICS"        "SNRPGP12"     "TMEM67"       "FNBP1P1"     
##  [91] "TAS2R14"      "HAUS3"        "C12orf60"     "NPM1P39"      "ANKRD36"     
##  [96] "PSIP1"        "OSGEPL1"      "AC096921.2"   "C4orf17"      "AL445523.1"  
## [101] "ZNF654"       "NDUFA5"       "AC092747.4"   "ZDBF2"        "TXLNG"       
## [106] "HNRNPC"       "DPY19L2P2"    "AC090571.1"   "GCC2"         "KIZ"         
## [111] "AL035456.1"   "PM20D2"       "DEFB131B"     "TUT4"         "RDH14"       
## [116] "RPS27A"       "SUSD5"        "RPL21"        "HELQ"         "PAIP2B"      
## [121] "ZRANB3"       "PREPL"        "ZNF43"        "TRPC1"        "THUMPD1"     
## [126] "PUS7L"        "ZNF773"       "ZEB1-AS1"     "VPS13A"       "PTPDC1"      
## [131] "ZNF626"       "SUZ12P1"      "ZNF770"       "SDAD1"        "AL137139.2"  
## [136] "OMA1"         "LATS1"        "RPL41"        "TM2D3"        "NOL11"       
## [141] "HNRNPH1"      "AL121583.1"   "ERGIC2"       "DIS3"         "NUBPL"       
## [146] "CUBN"         "CLEC2D"       "ZNRD1ASP"     "GPALPP1"      "AL353795.1"  
## [151] "FARP1"        "UBE2N"        "ASNSD1"       "FOXP1"        "ZNF506"      
## [156] "HMGN1"        "PGM2L1"       "CLN5"         "ZNF460-AS1"   "RPS3AP6"     
## [161] "BNIP3"        "RPS3AP26"     "ITGB3BP"      "TRMO"         "ZNF84"       
## [166] "RELCH"        "AC092640.1"   "AC009487.2"   "DDX50P1"      "AL845472.2"  
## [171] "AC104806.2"   "POT1"         "SLC3A1"       "TUBE1"        "SNHG14"      
## [176] "POLR2M"       "ORC5"         "REV3L"        "PDE5A"        "TTC3"        
## [181] "AC110611.1"   "ZNF431"       "TEX10"        "ARHGAP15"     "ZNF181"      
## [186] "AL512308.1"   "ARRDC3"       "NPM1P24"      "RGMB"         "AP000766.1"  
## [191] "CEP120"       "EIF4E"        "NAP1L4P3"     "ZSCAN30"      "RPS20P10"    
## [196] "FRA10AC1"     "MIGA1"        "KIF20B"       "PKIA"         "THNSL1"      
## [201] "DZIP3"        "TARS3"        "MTBP"         "AC023906.4"   "ZNF141"      
## [206] "COA1"         "GRIN3A"       "RPL21P75"     "TGS1"         "PSMA8"       
## [211] "ZNF708"       "PMPCB"        "AC243919.1"   "TTC14"        "PACRGL"      
## [216] "AC138150.1"   "ORC2"         "AC016957.1"   "AC133644.3"   "AC092656.1"  
## [221] "AC005912.1"   "TBCA"         "SNORD11"      "ZNF138"       "RNA5SP355"   
## [226] "LRPPRC"       "ZNF121"       "NPM1P6"       "RBM26"        "G2E3"        
## [231] "ANKRD18EP"    "RSBN1"        "AC008507.2"   "CLYBL-AS2"    "TRPC5"       
## [236] "ZNF546"       "MTREX"        "BBS2"         "SIRT1"        "IFT22"       
## [241] "TRMT11"       "MRPL50"       "EIF4A2"       "CCDC141"      "BRWD1"       
## [246] "CHTOP"        "ZNF248"       "NAP1L1P1"     "IMMP2L"       "USP37"       
## [251] "ZMAT1"        "AC004908.1"   "SCYL3"        "ZNF229"       "RASA1"       
## [256] "USP51"        "HBS1L"        "CEBPZ"        "GCSAM"        "RALGAPA1"    
## [261] "PMS2P11"      "NPM1"         "RAPGEF6"      "PABPC1P7"     "AC006539.2"  
## [266] "RPL12P8"      "CCDC18-AS1"   "ZNF354B"      "CCDC138"      "C11orf58"    
## [271] "AL023584.2"   "RBL1"         "NAP1L1"       "ELP2"         "CEP97"       
## [276] "THAP5"        "PPAT"         "UTP15"        "CENPCP1"      "AC026356.2"  
## [281] "SSB"          "AL049828.1"   "ZNF891"       "CASD1"        "EIF1AX"      
## [286] "PPWD1"        "NIT2"         "ZNF486"       "XPA"          "AL365361.1"  
## [291] "SINHCAF"      "TBC1D32"      "WDR75"        "THAP6"        "RIC3"        
## [296] "EPB41L5"      "TRIM23"       "ZBTB20-AS1"   "TUBD1"        "NBPF11"      
## [301] "EPC1"         "CWF19L2"      "ICE2"         "TMTC3"        "AC124016.3"  
## [306] "ARHGEF35-AS1" "RNASEH2B"     "AL356599.1"   "MTAP"         "TTN"         
## [311] "AP5M1"        "AC027801.5"   "MTERF3"       "NAA15"        "ESCO1"       
## [316] "NOC3L"        "RGPD2"        "AKAP11"       "SGPP2"        "ATL2"        
## [321] "CEP135"       "OTUD3"        "TTC23L"       "ZNF681"       "PPP4R3A"     
## [326] "KIAA1586"     "UTP20"        "METTL4"       "DCUN1D4"      "ANGEL2"      
## [331] "AP000560.1"   "WASHC3"       "AC118549.1"   "PTCD3"        "HSD17B7P2"   
## [336] "SRSF8"        "ZNF680"       "C18orf25"     "C12orf29"     "USP45"       
## [341] "HECTD2"       "IFT80"        "NBPF8"        "DDX18"        "AC092279.1"  
## [346] "ZNF658"       "LIN9"         "ZXDA"         "WDR33"        "LYRM7"       
## [351] "THAP5P1"      "NOP58"        "ZNF675"       "ZNF283"       "UTP23"       
## [356] "ZNF273"       "SLC16A1-AS1"  "ZNF480"       "AC011939.1"   "AL034379.1"  
## [361] "AL096803.2"   "ZNF717"       "TMEM161B"     "AC068700.1"   "GPR89B"      
## [366] "CEP44"        "AC006971.1"   "TBC1D15"      "ZMYM2"        "BRIX1"       
## [371] "DYNLT3"       "EEF1AKMT2"    "MICOS10"      "ORC4"         "DMTF1"       
## [376] "NT5DC1"       "DNAJC16"      "ZRANB2"       "MTHFD1"       "AP002433.2"  
## [381] "CHCHD7"       "TFAM"         "RPP30"        "TRMT13"       "NR1D2"       
## [386] "TNKS"         "FOXO1"        "AL158163.1"   "GPBP1"        "SETDB2"      
## [391] "TMEM161B-AS1" "SMAD4"        "SCAI"         "SMCHD1"       "ZNF430"      
## [396] "ACAT1"        "APPBP2"       "RFPL3S"       "FARSB"        "AC093157.1"  
## [401] "FANCM"        "TBCK"         "EXOSC3"       "SENP7"        "GTPBP10"     
## [406] "KPNA5"        "FBXL4"        "FASTKD2"      "RPS3A"        "FBXL3"       
## [411] "CNOT7"        "OTUD6B-AS1"   "UGCG"         "MTO1"         "HNRNPA1"     
## [416] "GORAB"        "RNF145"       "ZNF140"       "ZNF189"       "ZXDB"        
## [421] "AF129075.2"   "ZNF292"       "EFCAB7"       "AP000648.4"   "ARHGAP5"     
## [426] "GNPNAT1"      "COG3"         "CLK4"         "NBPF15"       "EML4"        
## [431] "KRR1"         "RAD51B"       "AC009318.1"   "AL360020.1"   "XPO4"        
## [436] "SEPSECS"      "RALGAPA1P1"   "FAM133B"      "PIBF1"        "SLC4A7"      
## [441] "LINC01184"    "BBIP1"        "ORC3"         "TRNT1"        "TTC3P1"      
## [446] "LSM8"         "DLG1"         "AC010978.1"   "PDE7A"        "PGM3"        
## [451] "GCFC2"        "MFSD8"        "PHF10"        "AC009505.1"   "N4BP2L2"     
## [456] "TRDMT1"       "CBWD5"

Boxplot Negative All_Samples

Boxplot Negative AML

Boxplot Negative Normal_BM

Boxplot Negative Normal_PB

Venn diagram

## [1] "N4BP2L2" "CENPCP1"

Signature LSC

LSC positive

## 
##    Blast      LSC      CLP      Ery     LMPP      CMP      GMP      HSC 
##       12        8        3        3        3        4        4        4 
##      MEP      MPP    Bcell CD4Tcell CD8Tcell     Mono   NKcell     pHSC 
##        4        4        4        4        4        4        4       12
## [1] 0.729845
## [1] 71
## [1] 79
## [1] 150
##   [1] "ACLY"       "PRKCA"      "GPC1"       "ATP6V1D"    "SUB1P3"    
##   [6] "SUB1P1"     "MT1F"       "GRPEL1"     "AC002519.2" "CTNNA1"    
##  [11] "AL139095.1" "AL137792.1" "NEK7"       "AC015802.3" "DAD1"      
##  [16] "NCAPD2"     "COL6A1"     "H3P8"       "SPATA18"    "H2BC17"    
##  [21] "TUBG1"      "GOLT1B"     "RAB2A"      "NCS1"       "PTPRS"     
##  [26] "CNPPD1"     "PRKCA-AS1"  "NAA40"      "ASAP2"      "PARD3"     
##  [31] "PHLDA3"     "AC063949.1" "HAUS1"      "CARS1"      "RIPK1"     
##  [36] "SLC25A23"   "MBOAT2"     "AGAP3"      "KIFC1"      "MRPS18B"   
##  [41] "SEPTIN8"    "TCFL5"      "SDCBP"      "CAPZB"      "SPCS2"     
##  [46] "ATP5F1CP1"  "PUF60"      "MDM2"       "KCTD14"     "ITGB1"     
##  [51] "FBXW9"      "CD99"       "AL031123.2" "COPG1"      "PRDM10"    
##  [56] "H2AZ2P1"    "MST1"       "DKK2"       "SDCBPP3"    "PPP2CB"    
##  [61] "INKA2"      "MCU"        "CNP"        "COPB1"      "AC022149.1"
##  [66] "BABAM1"     "HEATR9"     "CDYL"       "CYC1"       "FBXL6"     
##  [71] "RRP36"      "HOPX"       "NAIPP4"     "LINC00886"  "AC092653.2"
##  [76] "RNU6-91P"   "AC099778.1" "RPL36AP48"  "EIF4A1"     "AL008729.1"
##  [81] "RNA5SP68"   "RN7SL517P"  "AC091607.2" "EPX"        "F2RL1"     
##  [86] "FAM184B"    "ZNF528-AS1" "RSL1D1"     "HTR7P1"     "AC068282.1"
##  [91] "SLC4A5"     "METTL1"     "COX16"      "LINC02328"  "AC135050.3"
##  [96] "AC020550.1" "WDR5B"      "CAPS2"      "RPS7P15"    "GNAT2"     
## [101] "ABCC9"      "ZNF667-AS1" "EBAG9P1"    "AC073195.1" "ZNF667"    
## [106] "LINC01358"  "AL079342.2" "CBWD3"      "CLYBL"      "DIS3L2"    
## [111] "AC092329.4" "TMEM192"    "TYW3"       "AC096638.2" "WDR11-AS1" 
## [116] "TIMM9"      "AC011912.1" "MGLL"       "LATS2-AS1"  "TSPYL2"    
## [121] "IGHV1-3"    "SNORA38B"   "BACH1-IT1"  "NDN"        "AL162595.1"
## [126] "PROM1"      "AC092944.1" "UQCRC2P1"   "AL158070.1" "RPL13P4"   
## [131] "AC027801.3" "AC069209.2" "AC097634.1" "ZNF790-AS1" "ECHDC2"    
## [136] "ZNF527"     "SP2-AS1"    "RGS17P1"    "VN1R1"      "ZNF502"    
## [141] "CNIH3"      "AP5S1"      "WDPCP"      "AC073655.2" "CLNK"      
## [146] "HACL1"      "EBLN3P"     "MPI"        "GAREM1"     "LANCL1-AS1"

heatmap

##  [1] "ACLY"       "PRKCA"      "GPC1"       "ATP6V1D"    "SUB1P3"    
##  [6] "SUB1P1"     "MT1F"       "GRPEL1"     "AC002519.2" "CTNNA1"    
## [11] "AL139095.1" "AL137792.1" "NEK7"       "AC015802.3" "DAD1"      
## [16] "NCAPD2"     "COL6A1"     "H3P8"       "SPATA18"    "H2BC17"    
## [21] "TUBG1"      "GOLT1B"     "RAB2A"      "NCS1"       "PTPRS"     
## [26] "CNPPD1"     "PRKCA-AS1"  "NAA40"      "ASAP2"      "PARD3"     
## [31] "PHLDA3"     "AC063949.1" "HAUS1"      "CARS1"      "RIPK1"     
## [36] "SLC25A23"   "MBOAT2"     "AGAP3"      "KIFC1"      "MRPS18B"   
## [41] "SEPTIN8"    "TCFL5"      "SDCBP"      "CAPZB"      "SPCS2"     
## [46] "ATP5F1CP1"  "PUF60"      "MDM2"       "KCTD14"     "ITGB1"     
## [51] "FBXW9"      "CD99"       "AL031123.2" "COPG1"      "PRDM10"    
## [56] "H2AZ2P1"    "MST1"       "DKK2"       "SDCBPP3"    "PPP2CB"    
## [61] "INKA2"      "MCU"        "CNP"        "COPB1"      "AC022149.1"
## [66] "BABAM1"     "HEATR9"     "CDYL"       "CYC1"       "FBXL6"     
## [71] "RRP36"
##  [1] "HOPX"       "NAIPP4"     "LINC00886"  "AC092653.2" "RNU6-91P"  
##  [6] "AC099778.1" "RPL36AP48"  "EIF4A1"     "AL008729.1" "RNA5SP68"  
## [11] "RN7SL517P"  "AC091607.2" "EPX"        "F2RL1"      "FAM184B"   
## [16] "ZNF528-AS1" "RSL1D1"     "HTR7P1"     "AC068282.1" "SLC4A5"    
## [21] "METTL1"     "COX16"      "LINC02328"  "AC135050.3" "AC020550.1"
## [26] "WDR5B"      "CAPS2"      "RPS7P15"    "GNAT2"      "ABCC9"     
## [31] "ZNF667-AS1" "EBAG9P1"    "AC073195.1" "ZNF667"     "LINC01358" 
## [36] "AL079342.2" "CBWD3"      "CLYBL"      "DIS3L2"     "AC092329.4"
## [41] "TMEM192"    "TYW3"       "AC096638.2" "WDR11-AS1"  "TIMM9"     
## [46] "AC011912.1" "MGLL"       "LATS2-AS1"  "TSPYL2"     "IGHV1-3"   
## [51] "SNORA38B"   "BACH1-IT1"  "NDN"        "AL162595.1" "PROM1"     
## [56] "AC092944.1" "UQCRC2P1"   "AL158070.1" "RPL13P4"    "AC027801.3"
## [61] "AC069209.2" "AC097634.1" "ZNF790-AS1" "ECHDC2"     "ZNF527"    
## [66] "SP2-AS1"    "RGS17P1"    "VN1R1"      "ZNF502"     "CNIH3"     
## [71] "AP5S1"      "WDPCP"      "AC073655.2" "CLNK"       "HACL1"     
## [76] "EBLN3P"     "MPI"        "GAREM1"     "LANCL1-AS1"

Boxplot Total LSC

Boxplot Positive LSC

Boxplot Négative LSC

#export des vecteurs et corrélations